U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Crisp2 cysteine-rich secretory protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360445, updated on 29-Feb-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Crisp2provided by RGD
    Official Full Name
    cysteine-rich secretory protein 2provided by RGD
    Primary source
    RGD:621653
    See related
    Ensembl:ENSRNOG00000013225 AllianceGenome:RGD:621653
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tpx1; Crisp2l
    Summary
    Involved in cell-cell adhesion. Predicted to be active in extracellular space. Orthologous to human CRISP2 (cysteine rich secretory protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 5113.6) See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Crisp2 in Genome Data Viewer
    Location:
    9q13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (27604024..27628520)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (20107649..20131967)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (23503223..23527502)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily ac, polypeptide 1 Neighboring gene Rh-associated glycoprotein Neighboring gene exocrine gland-secreted peptide 1-like Neighboring gene ribosomal protein L36A, pseudogene 6

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular cloning of the rat Tpx-1 responsible for the interaction between spermatogenic and Sertoli cells. Maeda T, et al. Biochem Biophys Res Commun, 1998 Jul 9. PMID 9675100
    2. Identification of a rat testis-specific gene encoding a potential rat outer dense fibre protein. O'Bryan MK, et al. Mol Reprod Dev, 1998 Jul. PMID 9621307
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermatogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cysteine-rich secretory protein 2
    Names
    testis specific protein 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011710.2 → NP_001011710.1  cysteine-rich secretory protein 2 precursor

      See identical proteins and their annotated locations for NP_001011710.1

      Status: VALIDATED

      Source sequence(s)
      BC078799, CK469282
      UniProtKB/TrEMBL
      A6JJ62, F7FBM2, O88205, Q9R1L4
      Related
      ENSRNOP00000017996.4, ENSRNOT00000017996.7
      Conserved Domains (2) summary
      cd05383
      Location:36 → 172
      CAP_CRISP; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory proteins
      pfam08562
      Location:189 → 243
      Crisp

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      27604024..27628520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244643.5 → XP_006244705.1  cysteine-rich secretory protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006244705.1

      UniProtKB/TrEMBL
      A6JJ62, F7FBM2, O88205, Q9R1L4
      Conserved Domains (2) summary
      cd05383
      Location:36 → 172
      CAP_CRISP; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory proteins
      pfam08562
      Location:189 → 243
      Crisp

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_031240.1: Suppressed sequence

      Description
      NM_031240.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools