Glra1 glycine receptor, alpha 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Glra1provided by RGD
Official Full Name: glycine receptor, alpha 1provided by RGD
Primary source: RGD:2704
See related: Ensembl:ENSRNOG00000013588 AllianceGenome:RGD:2704
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GLYRA1
Summary: Enables extracellularly glycine-gated chloride channel activity; glycine binding activity; and identical protein binding activity. Involved in chloride transport and glycinergic synaptic transmission. Located in endoplasmic reticulum and external side of plasma membrane. Is active in calyx of Held and glycinergic synapse. Is integral component of postsynaptic specialization membrane and integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in hyperekplexia 1. Orthologous to human GLRA1 (glycine receptor alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 37.3) and Lung (RPKM 5.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (40128284..40228612, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (39625853..39727897, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (40851955..40954364, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Acidic pH reduces agonist efficacy and responses to synaptic-like glycine applications in zebrafish alpha1 and rat alpha1beta recombinant glycine receptors.
Title: Acidic pH reduces agonist efficacy and responses to synaptic-like glycine applications in zebrafish α1 and rat α1β recombinant glycine receptors.
gain-of-function GLRA1 mutations also cause hyperekplexia, although the mechanism is unknown. Here we identify two new gain-of-function mutations (I43F and W170S) and characterize these along with known gain-of-function mutations (Q226E, V280M, and R414H) to identify how they cause hyperekplexia.
Title: Investigating the Mechanism by Which Gain-of-function Mutations to the α1 Glycine Receptor Cause Hyperekplexia.
the role of gephyrin and glycine receptor (GlyR) in vestibular compensation, was investigated.
Title: Expression of glycine receptors and gephyrin in rat medial vestibular nuclei and flocculi following unilateral labyrinthectomy.
analysis of the SENP-1 mediated SUMOylation-dependent regulatory pathway for GlyR endocytosis, which may have important physiological implications for proper neuronal excitability
Title: Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation.
an essential secondary structural requirement for GlyR modulation by ethanol and G protein
Title: Evidence for α-helices in the large intracellular domain mediating modulation of the α1-glycine receptor by ethanol and Gβγ.
overexpressing the Glra1 subunite in rat neurons caused reduced potentition and enhanced inhibition by zinc.
Title: The GLRA1 missense mutation W170S associates lack of Zn2+ potentiation with human hyperekplexia.
Hypoxia alters the expression of the GABAA Ralpha receptors and glycine alpha1 receptor in the cerebral cortex during development.
Title: Effects of inhibitory amino acids on expression of GABAA Rα and glycine Rα1 in hypoxic rat cortical neurons during development.
Gephyrin-mediated gamma-aminobutyric acid type A and glycine receptor clustering relies on a common binding site
Title: Gephyrin-mediated γ-aminobutyric acid type A and glycine receptor clustering relies on a common binding site.
Activation and desensitization induce distinct conformational changes at the extracellular-transmembrane domain interface of the glycine receptor
Title: Activation and desensitization induce distinct conformational changes at the extracellular-transmembrane domain interface of the glycine receptor.
The steady state behavior of the recombinant homomeric alpha 1 glycine receptor has been analyzed at a range of low agonist concentrations.
Title: Openings of the rat recombinant alpha 1 homomeric glycine receptor as a function of the number of agonist molecules bound.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellularly glycine-gated chloride channel activity	IDA Inferred from Direct Assay more info	PubMed
enables extracellularly glycine-gated chloride channel activity	IEA Inferred from Electronic Annotation more info
enables extracellularly glycine-gated chloride channel activity	ISO Inferred from Sequence Orthology more info
enables extracellularly glycine-gated chloride channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables extracellularly glycine-gated ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables glycine binding	IDA Inferred from Direct Assay more info	PubMed
enables glycine binding	IEA Inferred from Electronic Annotation more info
enables glycine binding	ISO Inferred from Sequence Orthology more info
enables glycine binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables taurine binding	IEA Inferred from Electronic Annotation more info
enables taurine binding	ISO Inferred from Sequence Orthology more info
enables taurine binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in acrosome reaction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within acrosome reaction	ISO Inferred from Sequence Orthology more info
involved_in adult walking behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adult walking behavior	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ethanol	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to zinc ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to zinc ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to zinc ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemical synaptic transmission, postsynaptic	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transport	IDA Inferred from Direct Assay more info	PubMed
involved_in chloride transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in inhibitory postsynaptic potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inhibitory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in inhibitory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in inhibitory postsynaptic potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoatomic anion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in muscle contraction	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of transmission of nerve impulse	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transmission of nerve impulse	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transmission of nerve impulse	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within neuromuscular process	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process controlling posture	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuromuscular process controlling posture	ISO Inferred from Sequence Orthology more info
involved_in neuronal action potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of acrosome reaction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of acrosome reaction	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of respiratory gaseous exchange	ISO Inferred from Sequence Orthology more info
involved_in regulation of respiratory gaseous exchange by nervous system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of respiratory gaseous exchange by nervous system process	ISO Inferred from Sequence Orthology more info
involved_in response to alcohol	ISO Inferred from Sequence Orthology more info
involved_in response to alcohol	ISS Inferred from Sequence or Structural Similarity more info
involved_in righting reflex	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within righting reflex	ISO Inferred from Sequence Orthology more info
involved_in startle response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within startle response	ISO Inferred from Sequence Orthology more info
involved_in startle response	ISO Inferred from Sequence Orthology more info
involved_in startle response	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in synaptic transmission, glycinergic	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic transmission, glycinergic	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synaptic transmission, glycinergic	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, glycinergic	ISO Inferred from Sequence Orthology more info
involved_in visual perception	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual perception	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in calyx of Held	IDA Inferred from Direct Assay more info	PubMed
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in glycinergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glycinergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glycinergic synapse	ISO Inferred from Sequence Orthology more info
located_in inhibitory synapse	IEA Inferred from Electronic Annotation more info
located_in inhibitory synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info
part_of transmembrane transporter complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glycine receptor subunit alpha-1

Names: glycine receptor 48 kDa subunit; glycine receptor strychnine-binding subunit; glycine receptor, alpha 1 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.