Crlf2 cytokine receptor-like factor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Crlf2provided by RGD
Official Full Name: cytokine receptor-like factor 2provided by RGD
Primary source: RGD:621078
See related: Ensembl:ENSRNOG00000049828 AllianceGenome:RGD:621078
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Crl2; Tpte2; Tslpr
Summary: Enables cytokine activity. Predicted to be involved in several processes, including positive regulation of interleukin-5 production; positive regulation of mast cell activation; and positive regulation of receptor signaling pathway via STAT. Predicted to act upstream of or within inflammatory response. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Orthologous to human CRLF2 (cytokine receptor like factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 68.0), Spleen (RPKM 52.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (118932..123632)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (103943..108643)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (1456843..1461543, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

suggest that the formation of the ternary TSLPR : TSLP : IL-7Ralpha complex may activate STAT5 or a STAT5-related signaling pathway to mediate neuroinflammation in ischemic stroke
Title: Increased expression of thymic stromal lymphopoietin receptor in a rat model of middle cerebral artery occlusion.
A rat middle cerebral artery occlusion (MCAO) model was established, and it was demonstrated that the expression levels of TSLP and TSLPR were significantly increased in the infarct area between 12 and 72 h after MCAO.
Title: TSLP/TSLPR promote angiogenesis following ischemic stroke via activation of the PI3K/AKT pathway.
TSLP receptor is widely expressed in rats suggesting that TSLPR may have roles in signaling outside the hematopoietic system.
Title: Cloning of rat thymic stromal lymphopoietin receptor (TSLPR) and characterization of genomic structure of murine Tslpr gene.

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General gene information

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Markers

AI177846 (e-PCR)
- UniSTS:250472

RH141167 (e-PCR)
- UniSTS:223163

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokine receptor activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-5 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via STAT	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytokine receptor-like factor 2

Names: TSLP receptor; thymic stromal lymphopoietin protein receptor; thymic stromal-derived lymphopoietin, receptor; transmembrane phosphoinositide 3-phosphatase and tensin homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134465.2 → NP_604460.2 cytokine receptor-like factor 2 precursor

See identical proteins and their annotated locations for NP_604460.2

Status: PROVISIONAL

Source sequence(s)

BC078740

UniProtKB/Swiss-Prot

Q8R4S8

UniProtKB/TrEMBL

Q6AZ53

Conserved Domains (2) summary

cd00063
Location:124 → 192

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:41 → 93

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

118932..123632

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008769915.3 → XP_008768137.1 cytokine receptor-like factor 2 isoform X1

UniProtKB/Swiss-Prot

Q8R4S8

UniProtKB/TrEMBL

M0RA33

Related

ENSRNOP00000066370.2, ENSRNOT00000075656.2

Conserved Domains (2) summary

cd00063
Location:134 → 202

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:41 → 93

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039091600.1 → XP_038947528.1 cytokine receptor-like factor 2 isoform X2

UniProtKB/Swiss-Prot

Q8R4S8

Conserved Domains (1) summary

cd00063
Location:117 → 185

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039091601.1 → XP_038947529.1 cytokine receptor-like factor 2 isoform X3

UniProtKB/Swiss-Prot

Q8R4S8

Conserved Domains (1) summary

cd00063
Location:107 → 175

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039091603.2 → XP_038947531.1 cytokine receptor-like factor 2 isoform X4

Conserved Domains (1) summary

cd00063
Location:41 → 109

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039091602.2 → XP_038947530.1 cytokine receptor-like factor 2 isoform X4

Conserved Domains (1) summary

cd00063
Location:41 → 109

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...