CD84 CD84 molecule [Homo sapiens (human)] - Gene

Summary

Official Symbol: CD84provided by HGNC
Official Full Name: CD84 moleculeprovided by HGNC
Primary source: HGNC:HGNC:1704
See related: Ensembl:ENSG00000066294 MIM:604513; AllianceGenome:HGNC:1704
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LY9B; hCD84; mCD84; SLAMF5
Summary: This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
Expression: Broad expression in lymph node (RPKM 12.0), appendix (RPKM 11.0) and 19 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q23.3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (160541098..160579496, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (159678187..159716598, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (160510888..160549286, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD84 is a regulator of the immunosuppressive microenvironment in multiple myeloma.
Title: CD84 is a regulator of the immunosuppressive microenvironment in multiple myeloma.
Bone marrow dendritic cells support the survival of chronic lymphocytic leukemia cells in a CD84 dependent manner.
Title: Bone marrow dendritic cells support the survival of chronic lymphocytic leukemia cells in a CD84 dependent manner.
Among 29 immune and inflammatory proteins, CXCL1, CD84 and TNFRSF10A were associated with early post-acute coronary syndrome (ACS) after initial ACS-admission
Title: The temporal pattern of immune and inflammatory proteins prior to a recurrent coronary event in post-acute coronary syndrome patients.
our experiments identified SLAMF5 as a novel cell surface receptor modulator of autophagy and revealed an unexpected link between the SLAMF and IRF8 signaling pathways, both implicated in multiple human pathologies.
Title: Signaling Lymphocyte Activation Molecule Family 5 Enhances Autophagy and Fine-Tunes Cytokine Response in Monocyte-Derived Dendritic Cells via Stabilization of Interferon Regulatory Factor 8.
Results show that CD84 expressed on CLL cells interact with CD84 expressed on cells in their microenvironment, inducing cell survival in both sides.
Title: CD84 mediates CLL-microenvironment interactions.
up-regulated in Kawasaki disease arteriopathy
Title: CD84 is markedly up-regulated in Kawasaki disease arteriopathy.
data show that overexpression of CD84 in CLL is an important survival mechanism that appears to be an early event in the pathogenesis of the disease
Title: CD84 is a survival receptor for CLL cells.
These findings support a model in which CD84 genotypes and/or expression may serve as a useful biomarker for response to etanercept treatment in RA patients of European ancestry
Title: Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis.
CD84 is highly expressed in mast cells and that it contributes to the regulation of FcepsilonRI signaling
Title: CD84 negatively regulates IgE high-affinity receptor signaling in human mast cells.
These data suggest that CD84 may play a role in modulating Fc epsilon RI-mediated signaling in mast cells.
Title: The leukocyte receptor CD84 inhibits Fc epsilon RI-mediated signaling through homophilic interaction in transfected RBL-2H3 cells.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

GDB:434012 (e-PCR)
- UniSTS:157204

PMC156606P1 (e-PCR)
- UniSTS:271408

L17796 (e-PCR)
- UniSTS:12896

G16260 (e-PCR)
- UniSTS:70535

AL009296 (e-PCR)
- UniSTS:10702

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in defense response	TAS Traceable Author Statement more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	TAS Traceable Author Statement more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of granulocyte macrophage colony-stimulating factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of interleukin-18 production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of interleukin-6 production	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of mast cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mast cell degranulation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of monocyte chemotactic protein-1 production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of tumor necrosis factor production	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of macrophage activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of store-operated calcium entry	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: SLAM family member 5

Names: CD84 antigen (leukocyte antigen); cell surface antigen MAX.3; hly9-beta; leucocyte differentiation antigen CD84; leukocyte antigen CD84; leukocyte differentiation antigen CD84; signaling lymphocytic activation molecule 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001184879.2 → NP_001171808.1 SLAM family member 5 isoform 1 precursor

See identical proteins and their annotated locations for NP_001171808.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1). This variant has also been called CD84a.

Source sequence(s)

AF054816, AL138930, CA448708

Consensus CDS

CCDS53396.1

UniProtKB/Swiss-Prot

B2R8T1, B7Z3R8, O15430, O95266, O95660, Q5H9R1, Q6FHA8, Q8WLP1, Q8WWI8, Q9UF04, Q9UIB6, Q9UIB7, Q9UIB8, Q9UIT7

Related

ENSP00000312367.4, ENST00000311224.8

Conserved Domains (2) summary

cd05775
Location:31 → 129

Ig_SLAM-CD84_like_N; N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84_like

pfam13927
Location:134 → 197

Ig_3; Immunoglobulin domain
NM_001184881.2 → NP_001171810.1 SLAM family member 5 isoform 3 precursor

See identical proteins and their annotated locations for NP_001171810.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two alternate segments, one of which shifts the reading frame, compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct C-terminus when it is compared to isoform 1. This variant has also been called CD84d.

Source sequence(s)

AF054817, AL138930, CA448708

Consensus CDS

CCDS53397.1

UniProtKB/Swiss-Prot

Q9UIB8

Related

ENSP00000357030.3, ENST00000368051.3

Conserved Domains (2) summary

cd05775
Location:31 → 129

Ig_SLAM-CD84_like_N; N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84_like

pfam13927
Location:134 → 197

Ig_3; Immunoglobulin domain
NM_001184882.2 → NP_001171811.1 SLAM family member 5 isoform 4 precursor

See identical proteins and their annotated locations for NP_001171811.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two alternate segments, compared to variant 1. The resulting protein (isoform 4) is shorter when it is compared to isoform 1.

Source sequence(s)

AK296290, AL138930, CA448708

Consensus CDS

CCDS53395.1

UniProtKB/Swiss-Prot

Q9UIB8

Related

ENSP00000442845.1, ENST00000534968.5

Conserved Domains (1) summary

pfam13927
Location:20 → 83

Ig_3; Immunoglobulin domain
NM_001330742.2 → NP_001317671.1 SLAM family member 5 isoform 5 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (5) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AL138930

Consensus CDS

CCDS81388.1

UniProtKB/Swiss-Prot

Q9UIB8

Related

ENSP00000357027.3, ENST00000368048.7
NM_003874.4 → NP_003865.1 SLAM family member 5 isoform 2 precursor

See identical proteins and their annotated locations for NP_003865.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate, in-frame segment, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. This variant has also been called CD84c.

Source sequence(s)

AL138930, BC020063, CA448708

Consensus CDS

CCDS1206.1

UniProtKB/Swiss-Prot

Q9UIB8

Related

ENSP00000357033.4, ENST00000368054.8

Conserved Domains (2) summary

cd05775
Location:31 → 129

Ig_SLAM-CD84_like_N; N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84_like

pfam13927
Location:134 → 197

Ig_3; Immunoglobulin domain