Mpc2 mitochondrial pyruvate carrier 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mpc2provided by RGD
Official Full Name: mitochondrial pyruvate carrier 2provided by RGD
Primary source: RGD:1563422
See related: Ensembl:ENSRNOG00000003150 AllianceGenome:RGD:1563422
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Brp44; SLC54A2; RGD1563422
Summary: Predicted to enable identical protein binding activity and pyruvate transmembrane transporter activity. Predicted to be involved in mitochondrial pyruvate transmembrane transport. Predicted to act upstream of or within mitochondrial acetyl-CoA biosynthetic process from pyruvate and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in mitochondrion. Predicted to be integral component of mitochondrial inner membrane. Orthologous to human MPC2 (mitochondrial pyruvate carrier 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 1056.6), Kidney (RPKM 874.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q23

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (80261143..80280668)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (77728176..77747664)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (83680527..83700491)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of mitochondrial pyruvate carrier 2 aggravates neuronal injury in the cortex following cerebral ischemia in rat.
Title: Downregulation of mitochondrial pyruvate carrier 2 aggravates neuronal injury in the cortex following cerebral ischemia in rat.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA536926 (e-PCR)
- UniSTS:160011

RH139030 (e-PCR)
- UniSTS:221116

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables pyruvate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to pyruvate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables pyruvate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acetyl-CoA biosynthetic process from pyruvate	ISO Inferred from Sequence Orthology more info
involved_in acetyl-CoA biosynthetic process from pyruvate	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial pyruvate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial pyruvate transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrial pyruvate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial pyruvate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial pyruvate transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial pyruvate carrier 2

Names: brain protein 44; protein 0-44; solute carrier family 54 member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077643.2 → NP_001071111.1 mitochondrial pyruvate carrier 2 isoform 1

See identical proteins and their annotated locations for NP_001071111.1

Status: VALIDATED

Source sequence(s)

FM061478, JAXUCZ010000013

UniProtKB/Swiss-Prot

P38718

UniProtKB/TrEMBL

A6IDH0

Related

ENSRNOP00000004206.6, ENSRNOT00000004206.8

Conserved Domains (1) summary

pfam03650
Location:33 → 122

MPC; Uncharacterized protein family (UPF0041)
NM_001322942.1 → NP_001309871.1 mitochondrial pyruvate carrier 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A0A8I6AS07, A6IDG9

Related

ENSRNOP00000094616.1, ENSRNOT00000098110.1

Conserved Domains (1) summary

pfam03650
Location:33 → 81

MPC; Uncharacterized protein family (UPF0041)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

80261143..80280668

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006250126.4 → XP_006250188.1 mitochondrial pyruvate carrier 2 isoform X1

UniProtKB/Swiss-Prot

P38718

Conserved Domains (1) summary

pfam03650
Location:33 → 114

MPC; Uncharacterized protein family (UPF0041)