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    Crispld2 cysteine-rich secretory protein LCCL domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 78892, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Crispld2provided by MGI
    Official Full Name
    cysteine-rich secretory protein LCCL domain containing 2provided by MGI
    Primary source
    MGI:MGI:1926142
    See related
    Ensembl:ENSMUSG00000031825 AllianceGenome:MGI:1926142
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lgl1; Lcrisp2; coffeecrisp; 1810049K24Rik
    Summary
    Enables heparin binding activity. Acts upstream of or within extracellular matrix organization. Located in extracellular matrix. Is expressed in several structures, including alimentary system; cardiovascular system; metanephros; pituitary gland; and respiratory system. Orthologous to human CRISPLD2 (cysteine rich secretory protein LCCL domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in bladder adult (RPKM 60.1), ovary adult (RPKM 37.0) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 E1; 8 68.76 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (120719177..120779533)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (119992438..120052794)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53464 Neighboring gene STARR-positive B cell enhancer mm9_chr8:122434591-122434892 Neighboring gene ubiquitin specific peptidase 10 Neighboring gene STARR-seq mESC enhancer starr_22870 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:122556487-122556718 Neighboring gene RIKEN cDNA A130014A01 gene Neighboring gene zinc finger, DHHC domain containing 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of Betamethasone-Regulated Target Genes and Cell Pathways in Fetal Rat Lung Mesenchymal Fibroblasts. Seow BKL, et al. Endocrinology, 2019 Aug 1. PMID 31107524
    2. The novel lipopolysaccharide-binding protein CRISPLD2 is a critical serum protein to regulate endotoxin function. Wang ZQ, et al. J Immunol, 2009 Nov 15. PMID 19864597
    3. LGL1, a novel branching morphogen in developing kidney, is induced by retinoic acid. Quinlan J, et al. Am J Physiol Renal Physiol, 2007 Oct. PMID 17670908
    4. CRISPLD2: a novel NSCLP candidate gene. Chiquet BT, et al. Hum Mol Genet, 2007 Sep 15. PMID 17616516, Free PMC Article
    5. Annotation and analysis of 10,000 expressed sequence tags from developing mouse eye and adult retina. Yu J, et al. Genome Biol, 2003. PMID 14519200, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116029

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glycosaminoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosaminoglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within extracellular matrix organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in face morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in transport vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cysteine-rich secretory protein LCCL domain-containing 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310635.1 → NP_001297564.1  cysteine-rich secretory protein LCCL domain-containing 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001297564.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC120144, AK033858, AK132171, AV243162, AV380818, BY201813, CK626589
      Consensus CDS
      CCDS80939.1
      UniProtKB/Swiss-Prot
      Q3U4C7, Q8BZQ2, Q9D2R3
      Related
      ENSMUSP00000034282.10, ENSMUST00000034282.16
      Conserved Domains (3) summary
      smart00603
      Location:284 → 368
      LCCL; LCCL domain
      pfam03815
      Location:387 → 486
      LCCL; LCCL domain
      cl00133
      Location:56 → 201
      CAP; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family

    2. NM_030209.4 → NP_084485.1  cysteine-rich secretory protein LCCL domain-containing 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_084485.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC120144, AK019034, AK033858, AK132171, AV243162, AV380818, BC090642, CK626589
      Consensus CDS
      CCDS22714.1
      UniProtKB/Swiss-Prot
      Q8BZQ2
      Related
      ENSMUSP00000122962.2, ENSMUST00000132583.8
      Conserved Domains (3) summary
      smart00603
      Location:283 → 367
      LCCL; LCCL domain
      pfam03815
      Location:386 → 485
      LCCL; LCCL domain
      cl00133
      Location:56 → 201
      CAP; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      120719177..120779533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531508.1 → XP_006531571.1  cysteine-rich secretory protein LCCL domain-containing 2 isoform X1

      See identical proteins and their annotated locations for XP_006531571.1

      UniProtKB/Swiss-Prot
      Q3U4C7, Q8BZQ2, Q9D2R3
      Conserved Domains (3) summary
      smart00603
      Location:284 → 368
      LCCL; LCCL domain
      pfam03815
      Location:387 → 486
      LCCL; LCCL domain
      cl00133
      Location:56 → 201
      CAP; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family

    2. XM_006531509.1 → XP_006531572.1  cysteine-rich secretory protein LCCL domain-containing 2 isoform X2

      See identical proteins and their annotated locations for XP_006531572.1

      UniProtKB/Swiss-Prot
      Q8BZQ2
      Related
      ENSMUSP00000104600.4, ENSMUST00000108972.4
      Conserved Domains (3) summary
      smart00603
      Location:283 → 367
      LCCL; LCCL domain
      pfam03815
      Location:386 → 485
      LCCL; LCCL domain
      cl00133
      Location:56 → 201
      CAP; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZQ2.1 GenPept UniProtKB/Swiss-Prot:Q8BZQ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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