Elac2 elaC ribonuclease Z 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Elac2provided by MGI
Official Full Name: elaC ribonuclease Z 2provided by MGI
Primary source: MGI:MGI:1890496
See related: Ensembl:ENSMUSG00000020549 AllianceGenome:MGI:1890496
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hpc2; D11Wsu80e; 1110017O07Rik
Summary: Predicted to enable 3'-tRNA processing endoribonuclease activity and tRNA-specific ribonuclease activity. Predicted to be involved in mitochondrial tRNA 3'-trailer cleavage, endonucleolytic. Located in mitochondrial nucleoid. Is expressed in extraembryonic component. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 17. Orthologous to human ELAC2 (elaC ribonuclease Z 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 8.5), ovary adult (RPKM 7.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 40.42 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (64869856..64892906)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (64979030..65002080)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We show that ELAC2 is required for processing of tRNAs and for the balanced maintenance of C/D box snoRNAs, miRNAs, and a new class of tRNA fragments. We identify that correct biogenesis of regulatory non-coding RNAs is essential for both cytoplasmic and mitochondrial protein synthesis and the assembly of mitochondrial ribosomes and cytoplasmic polysomes.
Title: Concerted regulation of mitochondrial and nuclear non-coding RNAs by a dual-targeted RNase Z.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125885 (e-PCR)
- UniSTS:141833

NoName (e-PCR)
- UniSTS:236614

AU040829 (e-PCR)
- UniSTS:160108

RH124888 (e-PCR)
- UniSTS:161710

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-tRNA processing endoribonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info
enables tRNA-specific ribonuclease activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mitochondrial tRNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial tRNA 3'-end processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tRNA processing	IEA Inferred from Electronic Annotation more info
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial nucleoid	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc phosphodiesterase ELAC protein 2

Names: RNase Z 2; elaC homolog 2; elaC homolog protein 2; putative prostate cancer susceptibility protein; ribonuclease Z 2; tRNA 3 endonuclease 2; tRNase Z 2; tRNase Z(L)

NP_001349911.1

EC 3.1.26.11

NP_001349912.1

EC 3.1.26.11

NP_001349913.1

EC 3.1.26.11

NP_075968.2

EC 3.1.26.11

XP_006534128.1

EC 3.1.26.11

XP_006534129.1

EC 3.1.26.11

XP_006534130.1

EC 3.1.26.11

XP_006534131.1

EC 3.1.26.11

XP_030102124.1

EC 3.1.26.11

XP_036012824.1

EC 3.1.26.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362982.1 → NP_001349911.1 zinc phosphodiesterase ELAC protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AL663045

UniProtKB/TrEMBL

B1ATP7

Conserved Domains (2) summary

cd07718
Location:479 → 689

RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain

cd16296
Location:52 → 307

RNaseZ_ELAC2-N-term-like_MBL-fold; Ribonuclease Z, N-terminus of human ELAC2 and related proteins; MBL-fold metallo-hydrolase domain
NM_001362983.1 → NP_001349912.1 zinc phosphodiesterase ELAC protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AL663045

Consensus CDS

CCDS88171.1

UniProtKB/TrEMBL

B1ATP7

Related

ENSMUSP00000098610.3, ENSMUST00000101049.9

Conserved Domains (2) summary

cd07718
Location:479 → 684

RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain

cd16296
Location:52 → 307

RNaseZ_ELAC2-N-term-like_MBL-fold; Ribonuclease Z, N-terminus of human ELAC2 and related proteins; MBL-fold metallo-hydrolase domain
NM_001362984.1 → NP_001349913.1 zinc phosphodiesterase ELAC protein 2 isoform 4

Status: VALIDATED

Source sequence(s)

AL663045

Related

ENSMUST00000140369.2

Conserved Domains (1) summary

cd07718
Location:111 → 316

RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
NM_023479.3 → NP_075968.2 zinc phosphodiesterase ELAC protein 2 isoform 1

See identical proteins and their annotated locations for NP_075968.2

Status: VALIDATED

Source sequence(s)

AL663045, BC048235

Consensus CDS

CCDS24841.1

UniProtKB/Swiss-Prot

B1ATP6, Q80Y81, Q99MF0, Q99MF1, Q9CTA2, Q9D1A8, Q9EPZ2

UniProtKB/TrEMBL

B1ATP7, Q3U0M8

Related

ENSMUSP00000071788.6, ENSMUST00000071891.12

Conserved Domains (3) summary

COG1234
Location:478 → 748

ElaC; Ribonuclease BN, tRNA processing enzyme [Translation, ribosomal structure and biogenesis]

cd07718
Location:479 → 684

RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain

cd16296
Location:52 → 307

RNaseZ_ELAC2-N-term-like_MBL-fold; Ribonuclease Z, N-terminus of human ELAC2 and related proteins; MBL-fold metallo-hydrolase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

64869856..64892906

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534065.3 → XP_006534128.1 zinc phosphodiesterase ELAC protein 2 isoform X1

UniProtKB/TrEMBL

B1ATP7

Conserved Domains (2) summary

cd07718
Location:479 → 689

RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain

cd16296
Location:52 → 307

RNaseZ_ELAC2-N-term-like_MBL-fold; Ribonuclease Z, N-terminus of human ELAC2 and related proteins; MBL-fold metallo-hydrolase domain
XM_006534067.3 → XP_006534130.1 zinc phosphodiesterase ELAC protein 2 isoform X4

Conserved Domains (1) summary

cd07718
Location:111 → 321

RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
XM_006534068.2 → XP_006534131.1 zinc phosphodiesterase ELAC protein 2 isoform X5

Conserved Domains (1) summary

cd07718
Location:111 → 316

RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
XM_006534066.4 → XP_006534129.1 zinc phosphodiesterase ELAC protein 2 isoform X2

UniProtKB/TrEMBL

B1ATP7

Conserved Domains (2) summary

cd07718
Location:375 → 585

RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain

cl23716
Location:1 → 203

metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
XM_036156931.1 → XP_036012824.1 zinc phosphodiesterase ELAC protein 2 isoform X4

Conserved Domains (1) summary

cd07718
Location:111 → 321

RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
XM_030246264.2 → XP_030102124.1 zinc phosphodiesterase ELAC protein 2 isoform X3

UniProtKB/TrEMBL

B1ATP7

Conserved Domains (2) summary

cd07718
Location:375 → 580

RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain

cl23716
Location:1 → 203

metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain