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    Ncoa4 nuclear receptor coactivator 4 [ Mus musculus (house mouse) ]

    Gene ID: 27057, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Ncoa4provided by MGI
    Official Full Name
    nuclear receptor coactivator 4provided by MGI
    Primary source
    MGI:MGI:1350932
    See related
    Ensembl:ENSMUSG00000056234 AllianceGenome:MGI:1350932
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rfg; ARA70
    Summary
    Acts upstream of or within cellular iron ion homeostasis. Located in mitochondrion. Is expressed in several structures, including heart; lung; metanephros; reproductive system; and spleen. Orthologous to human NCOA4 (nuclear receptor coactivator 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14 (RPKM 63.2), liver E14.5 (RPKM 56.4) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 B; 14 19.4 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31881884..31901210)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (32159879..32179855)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41127 Neighboring gene beta-microseminoprotein Neighboring gene eukaryotic translation initiation factor 5 pseudogene Neighboring gene translocase of inner mitochondrial membrane 23 Neighboring gene STARR-seq mESC enhancer starr_36340 Neighboring gene predicted gene, 23946 Neighboring gene poly (ADP-ribose) glycohydrolase Neighboring gene STARR-positive B cell enhancer mm9_chr14:33042212-33042513 Neighboring gene tetratricopeptide repeat domain 35 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. cGAS-STING pathway aggravates early cerebral ischemia-reperfusion injury in mice by activating NCOA4-mediated ferritinophagy. Li B, et al. Exp Neurol, 2023 Jan. PMID 36343680
    2. NCOA4 links iron bioavailability to DNA metabolism. Federico G, et al. Cell Rep, 2022 Aug 16. PMID 35977492
    3. Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke. Li C, et al. Pharmacol Res, 2021 Dec. PMID 34634471
    4. Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis. Das NK, et al. Cell Metab, 2020 Jan 7. PMID 31708445, Free PMC Article
    5. NCOA4 Deficiency Impairs Systemic Iron Homeostasis. Bellelli R, et al. Cell Rep, 2016 Jan 26. PMID 26776506

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of NCOA4-mediated iron recycling ameliorates paraquat-induced lung injury by inhibiting ferroptosis.
      Title: Regulation of NCOA4-mediated iron recycling ameliorates paraquat-induced lung injury by inhibiting ferroptosis.
    2. Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4-mediated ferritinophagy.
      Title: Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy.
    3. A Novel Role of ARA70 in Regulating Ferritinophagy of RGCs During Retinal Ischemia Reperfusion.
      Title: A Novel Role of ARA70 in Regulating Ferritinophagy of RGCs During Retinal Ischemia Reperfusion.
    4. STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury.
      Title: STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury.
    5. ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4.
      Title: ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4.
    6. JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy.
      Title: JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy.
    7. cGAS-STING pathway aggravates early cerebral ischemia-reperfusion injury in mice by activating NCOA4-mediated ferritinophagy.
      Title: cGAS-STING pathway aggravates early cerebral ischemia-reperfusion injury in mice by activating NCOA4-mediated ferritinophagy.
    8. NCOA4 links iron bioavailability to DNA metabolism.
      Title: NCOA4 links iron bioavailability to DNA metabolism.
    9. The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages.
      Title: The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages.
    10. Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke.
      Title: Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC103382, 1110034E15Rik, 4432406M01Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein targeting to lysosome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in response to hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in autolysosome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    nuclear receptor coactivator 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033988.3 → NP_001029160.1  nuclear receptor coactivator 4 isoform a

      See identical proteins and their annotated locations for NP_001029160.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC154532
      Consensus CDS
      CCDS36863.1
      UniProtKB/TrEMBL
      Q3UI10, Q3UJ63, Q5U4H9, Q9WV42
      Related
      ENSMUSP00000126071.2, ENSMUST00000163336.8
      Conserved Domains (1) summary
      pfam12489
      Location:231 → 326
      ARA70; Nuclear coactivator

    2. NM_001284319.2 → NP_001271248.1  nuclear receptor coactivator 4 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 2. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AC154532
      UniProtKB/TrEMBL
      Q8BSH1
      Conserved Domains (1) summary
      pfam12489
      Location:136 → 231
      ARA70; Nuclear coactivator

    3. NM_001402998.1 → NP_001389927.1  nuclear receptor coactivator 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154532

    4. NM_001402999.1 → NP_001389928.1  nuclear receptor coactivator 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154532

    5. NM_001403000.1 → NP_001389929.1  nuclear receptor coactivator 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154532

    6. NM_001403001.1 → NP_001389930.1  nuclear receptor coactivator 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154532

    7. NM_001403002.1 → NP_001389931.1  nuclear receptor coactivator 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154532

    8. NM_001403003.1 → NP_001389932.1  nuclear receptor coactivator 4 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC154532
      UniProtKB/TrEMBL
      Q5U4H9

    9. NM_001403004.1 → NP_001389933.1  nuclear receptor coactivator 4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC154532

    10. NM_001403005.1 → NP_001389934.1  nuclear receptor coactivator 4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC154532

    11. NM_001403006.1 → NP_001389935.1  nuclear receptor coactivator 4 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154532

    12. NM_001403007.1 → NP_001389936.1  nuclear receptor coactivator 4 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC154532

    13. NM_001403008.1 → NP_001389937.1  nuclear receptor coactivator 4 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC154532

    14. NM_001403009.1 → NP_001389938.1  nuclear receptor coactivator 4 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC154532

    15. NM_001403010.1 → NP_001389939.1  nuclear receptor coactivator 4 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC154532

    16. NM_001403011.1 → NP_001389940.1  nuclear receptor coactivator 4 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC154532

    17. NM_019744.5 → NP_062718.2  nuclear receptor coactivator 4 isoform a

      See identical proteins and their annotated locations for NP_062718.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC154532
      Consensus CDS
      CCDS36863.1
      UniProtKB/TrEMBL
      Q3UI10, Q3UJ63, Q5U4H9, Q9WV42
      Related
      ENSMUSP00000107625.4, ENSMUST00000111994.10
      Conserved Domains (1) summary
      pfam12489
      Location:231 → 326
      ARA70; Nuclear coactivator

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      31881884..31901210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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