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    Rab28 RAB28, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 100972, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rab28provided by MGI
    Official Full Name
    RAB28, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:1917285
    See related
    Ensembl:ENSMUSG00000029128 AllianceGenome:MGI:1917285
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2700023P08Rik
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Acts upstream of or within toxin transport. Predicted to be located in ciliary basal body and ciliary rootlet. Predicted to be active in endomembrane system. Is expressed in bone; digit mesenchyme; and naris. Used to study cone-rod dystrophy 18. Human ortholog(s) of this gene implicated in cone-rod dystrophy 18. Orthologous to human RAB28 (RAB28, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 18.3), testis adult (RPKM 14.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 B3; 5 22.58 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (41782316..41865535, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (41624973..41708193, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 4754 Neighboring gene STARR-seq mESC enhancer starr_12947 Neighboring gene predicted gene, 35380 Neighboring gene STARR-positive B cell enhancer mm9_chr5:42099330-42099630 Neighboring gene STARR-seq mESC enhancer starr_12949 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide F pseudogene Neighboring gene predicted gene, 46910 Neighboring gene NK3 homeobox 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rab28 is a TBC1D1/TBC1D4 substrate involved in GLUT4 trafficking. Zhou Z, et al. FEBS Lett, 2017 Jan. PMID 27929607
    2. Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development. Verzi MP, et al. Gastroenterology, 2009 May. PMID 19208343, Free PMC Article
    3. Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain. Licatalosi DD, et al. Genes Dev, 2012 Jul 15. PMID 22802532, Free PMC Article
    4. Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport. Fukuda M, et al. J Biol Chem, 2002 Apr 5. PMID 11856727
    5. Extensive molecular differences between anterior- and posterior-half-sclerotomes underlie somite polarity and spinal nerve segmentation. Hughes DS, et al. BMC Dev Biol, 2009 May 22. PMID 19463158, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these findings reveal that RAB28 is required for shedding and phagocytosis of cone OS discs.
      Title: The small GTPase RAB28 is required for phagocytosis of cone outer segments by the murine retinal pigmented epithelium.
    2. Rab28 is a substrate for the GAP domains of both TBC1D1 and TBC1D4 in vitro.
      Title: Rab28 is a TBC1D1/TBC1D4 substrate involved in GLUT4 trafficking.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (6)  1 citation
    • Endonuclease-mediated (6) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC8039

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary rootlet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-28
    NP_001297518.1
    NP_001297519.1
    NP_001297521.1
    NP_081571.1
    XP_006503714.1
    XP_017176074.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310589.1 → NP_001297518.1  ras-related protein Rab-28 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (2) has a shorter, distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC102858, AC158920
      Consensus CDS
      CCDS80272.1
      UniProtKB/TrEMBL
      A0A0J9YV85
      Conserved Domains (1) summary
      cd04109
      Location:13 → 220
      Rab28; Rab GTPase family 28 (Rab28)

    2. NM_001310590.1 → NP_001297519.1  ras-related protein Rab-28 isoform 3

      See identical proteins and their annotated locations for NP_001297519.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate splice site in the 3' terminal exon and contains a distinct 3' coding region and 3' UTR compared to variant 1. The encoded isoform (3) has a shorter, distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC102858, AK012286, BY591132
      Consensus CDS
      CCDS80271.1
      UniProtKB/TrEMBL
      Q9CZQ8
      Related
      ENSMUSP00000144440.2, ENSMUST00000202913.2
      Conserved Domains (1) summary
      cl38936
      Location:13 → 193
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_001310592.1 → NP_001297521.1  ras-related protein Rab-28 isoform 4

      See identical proteins and their annotated locations for NP_001297521.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC102858, AK159493, AK161391, BY591132
      UniProtKB/TrEMBL
      Q3TTF7
      Conserved Domains (1) summary
      cl21455
      Location:1 → 144
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. NM_027295.3 → NP_081571.1  ras-related protein Rab-28 isoform 1

      See identical proteins and their annotated locations for NP_081571.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AC102858, AK159493, BB850234, BY591132
      Consensus CDS
      CCDS19258.1
      UniProtKB/Swiss-Prot
      Q99KL7
      UniProtKB/TrEMBL
      Q3TWY9
      Related
      ENSMUSP00000031011.9, ENSMUST00000031011.12
      Conserved Domains (2) summary
      smart00175
      Location:13 → 178
      RAB; Rab subfamily of small GTPases
      cd04109
      Location:13 → 221
      Rab28; Rab GTPase family 28 (Rab28)

    RNA

    1. NR_132325.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an internal exon in the 5' region and uses an alternate splice site in the 3' terminal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC102858, AC158920

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      41782316..41865535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320585.3 → XP_017176074.1  ras-related protein Rab-28 isoform X1

      UniProtKB/TrEMBL
      A0A0J9YV85
      Related
      ENSMUSP00000144541.2, ENSMUST00000201422.4
      Conserved Domains (1) summary
      cd04109
      Location:13 → 220
      Rab28; Rab GTPase family 28 (Rab28)

    2. XM_006503651.5 → XP_006503714.1  ras-related protein Rab-28 isoform X2

      Conserved Domains (1) summary
      cd04109
      Location:16 → 213
      Rab28; Rab GTPase family 28 (Rab28)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99KL7.1 GenPept UniProtKB/Swiss-Prot:Q99KL7

    Gene LinkOut

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