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    Cp190 Centrosomal protein 190kD [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41848, updated on 10-May-2024

    Summary

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    Official Symbol
    Cp190provided by FlyBase
    Official Full Name
    Centrosomal protein 190kDprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000283
    Locus tag
    Dmel_CG6384
    See related
    AllianceGenome:FB:FBgn0000283
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AbS1-4; Bx-63; Bx63; Cen185; Cen190; CEN190; CG6384; CP-190; CP-60; cp190; CP190; CP190_DROME; DMAP 190; DMAP-190; dmap190; Dmap190; DMAP190; Dmel\CG6384; E(mod)4-1; Map190; Rb188
    Summary
    Enables several functions, including POZ domain binding activity; chromatin insulator sequence binding activity; and protein homodimerization activity. Involved in several processes, including chromatin organization; nuclear axial expansion; and regulation of transcription, DNA-templated. Located in chromosome; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including adult head; embryonic brain; extended germ band embryo; and larval ventral nerve cord. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Cp190 in Genome Data Viewer
    Location:
    88E9-88E11; 3-56 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15270432..15275241, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11096154..11100963, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Set Neighboring gene ATP synthase, oligomycin sensitivity conferring protein Neighboring gene uncharacterized protein Neighboring gene Zinc/iron regulated transporter-related protein 88E Neighboring gene antisense RNA:CR46081 Neighboring gene uncharacterized protein Neighboring gene MORF-related gene 15 Neighboring gene lethal (3) neo43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Study of the in Vivo Functional Role of Mutations in the BTB Domain of the CP190 Protein of Drosophila melanogaster. Fedotova AA, et al. Dokl Biochem Biophys, 2023 Apr. PMID 37340291
    2. [Insulator Protein CP190 Regulates Expression of Spermatocyte Differentiation Genes in Drosophila melanogaster Male Germline]. Romanov SE, et al. Mol Biol (Mosk), 2023 Jan-Feb. PMID 36976746
    3. Analysis of Chromatin Interactions Mediated by Specific Architectural Proteins in Drosophila Cells. Ando-Kuri M, et al. Methods Mol Biol, 2018. PMID 29605857, Free PMC Article
    4. Newly Characterized Region of CP190 Associates with Microtubules and Mediates Proper Spindle Morphology in Drosophila Stem Cells. Plevock KM, et al. PLoS One, 2015. PMID 26649574, Free PMC Article
    5. Functional sub-division of the Drosophila genome via chromatin looping: the emerging importance of CP190. Ahanger SH, et al. Nucleus, 2013 Mar-Apr. PMID 23333867, Free PMC Article

    See all (337) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The N-Terminal Part of Drosophila CP190 Is a Platform for Interaction with Multiple Architectural Proteins.
      Title: The N-Terminal Part of Drosophila CP190 Is a Platform for Interaction with Multiple Architectural Proteins.
    2. The MADF-BESS Protein CP60 Is Recruited to Insulators via CP190 and Has Redundant Functions in Drosophila.
      Title: The MADF-BESS Protein CP60 Is Recruited to Insulators via CP190 and Has Redundant Functions in Drosophila.
    3. Study of the in Vivo Functional Role of Mutations in the BTB Domain of the CP190 Protein of Drosophila melanogaster.
      Title: Study of the in Vivo Functional Role of Mutations in the BTB Domain of the CP190 Protein of Drosophila melanogaster.
    4. [Insulator Protein CP190 Regulates Expression of Spermatocyte Differentiation Genes in Drosophila melanogaster Male Germline].
      Title: [Insulator Protein CP190 Regulates Expression of Spermatocyte Differentiation Genes in Drosophila melanogaster Male Germline].
    5. CTCF, BEAF-32, and CP190 are not required for the establishment of TADs in early Drosophila embryos but have locus-specific roles.
      Title: CTCF, BEAF-32, and CP190 are not required for the establishment of TADs in early Drosophila embryos but have locus-specific roles.
    6. Topological screen identifies hundreds of Cp190- and CTCF-dependent Drosophila chromatin insulator elements.
      Title: Topological screen identifies hundreds of Cp190- and CTCF-dependent Drosophila chromatin insulator elements.
    7. Mechanism and functional role of the interaction between CP190 and the architectural protein Pita in Drosophila melanogaster.
      Title: Mechanism and functional role of the interaction between CP190 and the architectural protein Pita in Drosophila melanogaster.
    8. Human CTCF Interacts with Drosophila CP190, but not with Kaiso.
      Title: Human CTCF Interacts with Drosophila CP190, but not with Kaiso.
    9. M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity.
      Title: M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity.
    10. HIPP1 stabilizes the interaction between CP190 and Su(Hw) in the Drosophila insulator complex.
      Title: HIPP1 stabilizes the interaction between CP190 and Su(Hw) in the Drosophila insulator complex.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables POZ domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin insulator sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin looping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin boundary formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nuclear axial expansion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pericentriolar material IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centrosomal protein 190kD
    Names
    CG6384-PA
    CG6384-PB
    Cp190-PA
    Cp190-PB
    E(mod)4-1
    centrosomal protein 190
    centrosomal protein 190 kD
    centrosomal protein 190 kDa
    centrosomal protein 90
    centrosomal protein of 190 kDa
    enhancer of mod(mdg4)4-1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15270432..15275241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079635.3 → NP_524359.2  centrosomal protein 190kD, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524359.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2Y3, Q24478, Q9VFA1
      Related
      FBpp0082580
      Conserved Domains (3) summary
      smart00225
      Location:31 → 127
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00020
      Location:540 → 568
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:20 → 122
      BTB; BTB/POZ domain

    2. NM_169632.2 → NP_731998.1  centrosomal protein 190kD, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731998.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2Y3, Q24478, Q9VFA1
      Related
      FBpp0082581
      Conserved Domains (3) summary
      smart00225
      Location:31 → 127
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00020
      Location:540 → 568
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:20 → 122
      BTB; BTB/POZ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24478.2 Q24478

    Gene LinkOut

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