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    Klp59C Kinesin-like protein at 59C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37671, updated on 10-May-2024

    Summary

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    Official Symbol
    Klp59Cprovided by FlyBase
    Official Full Name
    Kinesin-like protein at 59Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034824
    Locus tag
    Dmel_CG3219
    See related
    AllianceGenome:FB:FBgn0034824
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3219; DmCG3219; Dmel\CG3219; DmKlp59C; DmKLP59C; KIF 2B; KIF2A/B/C; KLP59C
    Summary
    Enables cytoskeletal motor activity. Predicted to be involved in microtubule-based movement. Located in kinetochore microtubule. Is expressed in adult head. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 3. Orthologous to human KIF2A (kinesin family member 2A). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Klp59C in Genome Data Viewer
    Location:
    59C4-59C4; 2-102 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23123923..23126042, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19011446..19013565, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44781 Neighboring gene long non-coding RNA:CR44782 Neighboring gene long non-coding RNA:CR44455 Neighboring gene long non-coding RNA:CR44456

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. KLP10A and KLP59C: the dynamic duo of microtubule depolymerization. Sharp DJ, et al. Cell Cycle, 2005 Nov. PMID 16205125
    2. A Kin I-dependent Pacman-flux mechanism for anaphase A. Sharp DJ, et al. Cell Cycle, 2004 Jun. PMID 15153812
    3. Cell division: burning the spindle at both ends. Heald RW. Nature, 2004 Jan 22. PMID 14737150
    4. Expression levels of a kinesin-13 microtubule depolymerase modulates the effectiveness of anti-microtubule agents. Schimizzi GV, et al. PLoS One, 2010 Jun 30. PMID 20614032, Free PMC Article
    5. Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase. Rogers GC, et al. Nature, 2004 Jan 22. PMID 14681690

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal motor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Kinesin-like protein at 59C
    Names
    CG3219-PA
    Kinesin13C
    Klp59C-PA
    kinesin-13

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23123923..23126042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137915.4 → NP_611759.1  Kinesin-like protein at 59C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611759.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W1U4
      UniProtKB/TrEMBL
      Q45EX0
      Related
      FBpp0071885
      Conserved Domains (2) summary
      cd01367
      Location:187 → 519
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
      pfam00225
      Location:193 → 520
      Kinesin; Kinesin motor domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W1U4.1 Q9W1U4

    Gene LinkOut

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