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    Mocs1 Molybdenum cofactor synthesis 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39238, updated on 10-May-2024

    Summary

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    Official Symbol
    Mocs1provided by FlyBase
    Official Full Name
    Molybdenum cofactor synthesis 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0263241
    Locus tag
    Dmel_CG33048
    See related
    AllianceGenome:FB:FBgn0263241
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG33048; CG7858; Dmel\CG33048; lxd; Mocs1A; MOCS1A; Mocs1A-B; Mocs1B; MOCS1B; mocsI; MocsI; MOCSI; Mosc1A+Mosc1B; pfs
    Summary
    Predicted to enable GTP 3',8'-cyclase activity and cyclic pyranopterin monophosphate synthase activity. Involved in inter-male aggressive behavior. Predicted to be part of molybdopterin synthase complex. Is expressed in central nervous system; imaginal disc; and photoreceptor cell. Human ortholog(s) of this gene implicated in molybdenum cofactor deficiency type A. Orthologous to human MOCS1 (molybdenum cofactor synthesis 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    68A4-68A4; 3-34 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11070526..11073348)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11063626..11066448)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Suppressor of Under-Replication Neighboring gene uncharacterized protein Neighboring gene Prefoldin 2 Neighboring gene Nucleolar complex protein 1 Neighboring gene JIL-1 kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleotide variations in the lxd region of Drosophila melanogaster: characterization of a candidate modifier of lifespan. Tahoe NM, et al. Gene, 2002 Sep 4. PMID 12384303
    2. Effect of adenine metabolites on survival of Drosophila melanogaster of low xanthine dehydrogenase activity. Ho YK, et al. Comp Biochem Physiol B, 1992 Oct. PMID 1424569
    3. Nutritional control of xanthine dehydrogenase. II. Effects on xanthine dehydrogenase and aldehyde oxidase of culturing wild-type and mutant Drosophila on different levels of molybdenum. Duke EJ, et al. Biochem Genet, 1975 Feb. PMID 806286
    4. The peacefulness gene promotes aggression in Drosophila. Ramin M, et al. Mol Brain, 2019 Jan 3. PMID 30606245, Free PMC Article
    5. Genetical toxicogenomics in Drosophila identifies master-modulatory loci that are regulated by developmental exposure to lead. Ruden DM, et al. Neurotoxicology, 2009 Nov. PMID 19737576, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP 3',8'-cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP 3',8'-cyclase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclic pyranopterin monophosphate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclic pyranopterin monophosphate synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Mo-molybdopterin cofactor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Mo-molybdopterin cofactor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Mo-molybdopterin cofactor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in inter-male aggressive behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of molybdopterin synthase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    molybdenum cofactor synthesis 1
    Names
    CG33048-PA
    CG33048-PC
    Mocs1-PA
    Mocs1-PC
    low xanthine dehydrogenase
    molybdenum cofactor synthesis 1 ortholog
    peacefulness
    NP_788494.1
    NP_788495.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11070526..11073348
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176316.2 → NP_788494.1  molybdenum cofactor synthesis 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788494.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IQF1, Q9NIG3, Q9NIG4, Q9VTE4
      Related
      FBpp0075935
      Conserved Domains (4) summary
      cd01335
      Location:74 → 249
      Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
      PRK00164
      Location:59 → 366
      moaA; molybdenum cofactor biosynthesis protein A; Reviewed
      PRK09364
      Location:399 → 555
      moaC; molybdenum cofactor biosynthesis protein MoaC; Provisional
      pfam06463
      Location:240 → 367
      Mob_synth_C; Molybdenum Cofactor Synthesis C

    2. NM_176317.2 → NP_788495.1  molybdenum cofactor synthesis 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788495.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IQF1
      Related
      FBpp0075934
      Conserved Domains (3) summary
      cd01335
      Location:74 → 249
      Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
      PLN02951
      Location:43 → 385
      PLN02951; Molybderin biosynthesis protein CNX2
      pfam06463
      Location:240 → 367
      Mob_synth_C; Molybdenum Cofactor Synthesis C
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8I688 Q8I688
    Q8IQF1.1 Q8IQF1
    Q9NIG2 Q9NIG2

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