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    Duba Deubiquitinating enzyme A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39302, updated on 10-May-2024

    Summary

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    Official Symbol
    Dubaprovided by FlyBase
    Official Full Name
    Deubiquitinating enzyme Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036180
    Locus tag
    Dmel_CG6091
    See related
    AllianceGenome:FB:FBgn0036180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6091; Dmel\CG6091; ped; Q9VTK7
    Summary
    Enables Lys63-specific deubiquitinase activity. Involved in negative regulation of canonical Wnt signaling pathway and sperm individualization. Is expressed in several structures, including embryonic brain; extended germ band embryo; germline cell; gonad; and larval ventral nerve cord. Orthologous to human OTUD5 (OTU deubiquitinase 5). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Duba in Genome Data Viewer
    Location:
    68C15-68C15; 3-36 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11605436..11609465, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11598536..11602565, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mucin 68Ca

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems. Hofmann K, et al. Trends Biochem Sci, 2001 Jun. PMID 11406394
    2. Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways. Cho JH, et al. Cell Death Differ, 2021 Mar. PMID 33110214, Free PMC Article
    3. The de-ubiquitylating enzyme DUBA is essential for spermatogenesis in Drosophila. Koerver L, et al. Cell Death Differ, 2016 Dec. PMID 27518434, Free PMC Article
    4. Prp8 regulates oncogene-induced hyperplastic growth in Drosophila. Fernández-Espartero CH, et al. Development, 2018 Nov 12. PMID 30333215, Free PMC Article
    5. Genome-Wide Analysis Reveals Novel Regulators of Growth in Drosophila melanogaster. Vonesch SC, et al. PLoS Genet, 2016 Jan. PMID 26751788, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DUBA phosphorylation and catalytic activity are crucial in vivo for DUBA function in spermatogenesis.
      Title: The de-ubiquitylating enzyme DUBA is essential for spermatogenesis in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables K63-linked deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K63-linked deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    deubiquitinating enzyme A
    Names
    CG6091-PD
    CG6091-PE
    CG6091-PF
    CG6091-PG
    Duba-PD
    Duba-PE
    Duba-PF
    Duba-PG
    NP_001163417.1
    NP_648482.3
    NP_729723.2
    NP_729724.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11605436..11609465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168465.5 → NP_729723.2  deubiquitinating enzyme A, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729723.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQP6, Q95S49, Q9VTK7
      Conserved Domains (1) summary
      cl19932
      Location:224 → 334
      OTU; OTU-like cysteine protease

    2. NM_140225.6 → NP_648482.3  deubiquitinating enzyme A, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648482.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQP6, Q95S49, Q9VTK7
      Conserved Domains (1) summary
      cl19932
      Location:224 → 334
      OTU; OTU-like cysteine protease

    3. NM_001169946.2 → NP_001163417.1  deubiquitinating enzyme A, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163417.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIE7, Q95S49
      Conserved Domains (1) summary
      cl19932
      Location:224 → 334
      OTU; OTU-like cysteine protease

    4. NM_168466.4 → NP_729724.2  deubiquitinating enzyme A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729724.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NP6, Q8IQF9
      Conserved Domains (1) summary
      cl19932
      Location:64 → 174
      OTU; OTU-like cysteine protease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JIE7 E1JIE7
    Q8IQF9 Q8IQF9
    Q95S49 Q95S49
    Q9VTK7 Q9VTK7

    Gene LinkOut

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