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    Dbp21E2 DEAD box protein 21E2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33254, updated on 10-May-2024

    Summary

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    Official Symbol
    Dbp21E2provided by FlyBase
    Official Full Name
    DEAD box protein 21E2provided by FlyBase
    Primary source
    FLYBASE:FBgn0086130
    Locus tag
    Dmel_CG3561
    See related
    AllianceGenome:FB:FBgn0086130
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg3561; CG3561; Dmel\CG3561; DmRH9; KH1
    Summary
    Predicted to enable helicase activity. Predicted to be involved in mitochondrial large ribosomal subunit assembly. Located in cytoplasm. Is expressed in anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Orthologous to human DDX28 (DEAD-box helicase 28). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Dbp21E2 in Genome Data Viewer
    Location:
    21E2-21E2; 2-1.5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (811584..813380)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (811584..813380)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45259 Neighboring gene Nnf1b Neighboring gene SAGA factor-like TAF6 Neighboring gene Peroxin 12 Neighboring gene uncharacterized protein Neighboring gene Post-GPI attachment to proteins 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Nnf1 paralogs are partially redundant for somatic and germ line kinetochore function. Blattner AC, et al. Chromosoma, 2017 Feb. PMID 26892014
    2. A role for the cytoplasmic DEAD box helicase Dbp21E2 in rhodopsin maturation and photoreceptor viability. Hibbard KL, et al. J Neurogenet, 2012 Jun. PMID 22794106, Free PMC Article
    3. The SAGA core module is critical during Drosophila oogenesis and is broadly recruited to promoters. Soffers JHM, et al. PLoS Genet, 2021 Nov. PMID 34807910, Free PMC Article
    4. Elba, a novel developmentally regulated chromatin boundary factor is a hetero-tripartite DNA binding complex. Aoki T, et al. Elife, 2012 Dec 13. PMID 23240086, Free PMC Article
    5. DDX56 Binds to Chikungunya Virus RNA To Control Infection. Taschuk F, et al. mBio, 2020 Oct 27. PMID 33109765, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial large ribosomal subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DEAD box protein 21E2
    Names
    CG3561-PA
    Dbp21E2-PA
    KH1
    NP_608544.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      811584..813380
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134700.4 → NP_608544.1  DEAD box protein 21E2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608544.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VPT3
      Related
      FBpp0077674
      Conserved Domains (3) summary
      smart00487
      Location:126 → 330
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:343 → 462
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cl21455
      Location:113 → 314
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPT3 Q9VPT3

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