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    Fad2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44006, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Fad2provided by FlyBase
    Primary source
    FLYBASE:FBgn0029172
    Locus tag
    Dmel_CG7923
    See related
    AllianceGenome:FB:FBgn0029172
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7923; desatF; DesatF; desatF-alpha; Dmel CPVD; Dmel\CG7923; dsat-F; fad; fad2
    Summary
    Predicted to enable iron ion binding activity and stearoyl-CoA 9-desaturase activity. Involved in courtship behavior and pheromone metabolic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult heart; adult oenocyte; and organism. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 79. Orthologous to human SCD5 (stearoyl-CoA desaturase 5). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    68A1-68A1; 3-34 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11023535..11024846)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11016635..11017946)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45745 Neighboring gene klumpfuss Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Altered pheromone biosynthesis is associated with sex-specific changes in life span and behavior in Drosophila melanogaster. Joseph NM, et al. Mech Ageing Dev, 2018 Dec. PMID 30312624
    2. Identification of quantitative trait loci function through analysis of multiple cuticular hydrocarbons differing between Drosophila simulans and Drosophila sechellia females. Gleason JM, et al. Heredity (Edinb), 2009 Nov. PMID 19654611
    3. Evolution of a desaturase involved in female pheromonal cuticular hydrocarbon biosynthesis and courtship behavior in Drosophila. Legendre A, et al. Insect Biochem Mol Biol, 2008 Feb. PMID 18207084
    4. Contribution of oenocytes and pheromones to courtship behaviour in Drosophila. Wicker-Thomas C, et al. BMC Biochem, 2009 Aug 11. PMID 19671131, Free PMC Article
    5. A model-based analysis of chemical and temporal patterns of cuticular hydrocarbons in male Drosophila melanogaster. Kent C, et al. PLoS One, 2007 Sep 26. PMID 17896002, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. desatF is involved in the synthesis of 7,11-dienes; D. melanogaster/D. simulans hybrids with a chromosomal deletion of the gene had no dienes and received normal courtship from D. simulans males
      Title: Evolution of a desaturase involved in female pheromonal cuticular hydrocarbon biosynthesis and courtship behavior in Drosophila.
    2. desatF is a crucial enzyme for female pheromone biosynthesis and courtship behaviour in D. melanogaster.
      Title: A female-specific desaturase gene responsible for diene hydrocarbon biosynthesis and courtship behaviour in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables iron ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables stearoyl-CoA 9-desaturase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables stearoyl-CoA 9-desaturase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pheromone metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in unsaturated fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Fad2
    Names
    CG7923-PA
    Fad2-PA
    desaturase-F
    NP_651966.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11023535..11024846
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143709.3 → NP_651966.2  Fad2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651966.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4IY13, Q9VTD4
      Related
      FBpp0075926
      Conserved Domains (1) summary
      cd03505
      Location:68 → 309
      Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NFT2 Q9NFT2
    Q9VTD4 Q9VTD4

    Gene LinkOut

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