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    CG42335 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42558, updated on 10-May-2024

    Summary

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    Official Symbol
    CG42335provided by FlyBase
    Primary source
    FLYBASE:FBgn0259237
    Locus tag
    Dmel_CG42335
    See related
    AllianceGenome:FB:FBgn0259237
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13420; CG31177; CG5845; Dmel\CG42335
    Old locus tag
    Dmel_CG13420; Dmel_CG31177
    Summary
    Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm. Orthologous to human LVRN (laeverin) and TRHDE (thyrotropin releasing hormone degrading enzyme). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG42335 in Genome Data Viewer
    Location:
    93F9-93F9; 3-73 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21758764..21769301)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17584486..17595023)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene metabotropic GABA-B receptor subtype 2 Neighboring gene Bursicon

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Condensin II subunit dCAP-D3 restricts retrotransposon mobilization in Drosophila somatic cells. Schuster AT, et al. PLoS Genet, 2013 Oct. PMID 24204294, Free PMC Article
    2. Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster. Heinrichsen ET, et al. Mol Metab, 2014 Feb. PMID 24567903, Free PMC Article
    3. Genetic analysis of dPsa, the Drosophila orthologue of puromycin-sensitive aminopeptidase, suggests redundancy of aminopeptidases. Schulz C, et al. Dev Genes Evol, 2001 Dec. PMID 11819115
    4. Unanchored ubiquitin chains do not lead to marked alterations in gene expression in Drosophila melanogaster. Blount JR, et al. Biol Open, 2019 May 30. PMID 31097444, Free PMC Article
    5. Genome-wide identification and comparative analysis of Cry toxin receptor families in 7 insect species with a focus on Spodoptera litura. Li Q, et al. Insect Sci, 2022 Jun. PMID 34405540

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG42335-PE
    NP_732655.3
    • frameshift

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21758764..21769301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169967.3 → NP_732655.3  uncharacterized protein Dmel_CG42335 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732655.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VD85
      Conserved Domains (3) summary
      cd09601
      Location:34 → 492
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:26 → 425
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:567 → 874
      ERAP1_C; ERAP1-like C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95SM7 Q95SM7
    Q9VD85 Q9VD85

    Gene LinkOut

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