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    Pfdn2 Prefoldin 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 46121, updated on 10-May-2024

    Summary

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    Official Symbol
    Pfdn2provided by FlyBase
    Official Full Name
    Prefoldin 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0010741
    Locus tag
    Dmel_CG6302
    See related
    AllianceGenome:FB:FBgn0010741
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6302; Dmel\CG6302; l(3)01239; l(3)j9B4; P01239; pfdn2
    Summary
    Predicted to enable protein folding chaperone. Involved in establishment or maintenance of neuroblast polarity. Part of prefoldin complex. Is expressed in embryonic/larval brain; ganglion mother cell; larval neuroblast; secondary neuroblast; and spermatozoon. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to several human genes including PFDN2 (prefoldin subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    68A4-68A4; 3-34 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11073292..11074388, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11066392..11067488, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Suppressor of Under-Replication Neighboring gene uncharacterized protein Neighboring gene Molybdenum cofactor synthesis 1 Neighboring gene Nucleolar complex protein 1 Neighboring gene JIL-1 kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and phenotypic analysis of alleles of the Drosophila chromosomal JIL-1 kinase reveals a functional requirement at multiple developmental stages. Zhang W, et al. Genetics, 2003 Nov. PMID 14668387, Free PMC Article
    2. Prefoldin and Pins synergistically regulate asymmetric division and suppress dedifferentiation. Zhang Y, et al. Sci Rep, 2016 Mar 30. PMID 27025979, Free PMC Article
    3. The Drosophila suppressor of underreplication protein binds to late-replicating regions of polytene chromosomes. Makunin IV, et al. Genetics, 2002 Mar. PMID 11901119, Free PMC Article
    4. Misato Controls Mitotic Microtubule Generation by Stabilizing the TCP-1 Tubulin Chaperone Complex [corrected]. Palumbo V, et al. Curr Biol, 2015 Jun 29. PMID 26096973, Free PMC Article
    5. Down-regulation of torp4a, encoding the Drosophila homologue of torsinA, results in increased neuronal degeneration. Muraro NI, et al. J Neurobiol, 2006 Oct. PMID 16967506

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prefoldin acts synergistically with Pins to regulate asymmetric division of both neuroblasts and Intermediate Neural Progenitors.
      Title: Prefoldin and Pins synergistically regulate asymmetric division and suppress dedifferentiation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment or maintenance of neuroblast polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of prefoldin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of prefoldin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    prefoldin 2
    Names
    CG6302-PA
    CG6302-PB
    Pfdn2-PA
    Pfdn2-PB
    lethal (3) 01239
    prefoldin beta-like subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11073292..11074388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274767.1 → NP_001261696.1  prefoldin 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261696.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C6SV13, Q9VTE5
      UniProtKB/TrEMBL
      M9PF40
      Conserved Domains (1) summary
      pfam01920
      Location:13 → 115
      Prefoldin_2; Prefoldin subunit

    2. NM_168438.2 → NP_729659.1  prefoldin 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729659.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C6SV13, Q9VTE5
      UniProtKB/TrEMBL
      M9PF40
      Related
      FBpp0075967
      Conserved Domains (1) summary
      pfam01920
      Location:13 → 115
      Prefoldin_2; Prefoldin subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PF40 M9PF40
    Q9VTE5.1 Q9VTE5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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