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    SerRS Seryl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33518, updated on 10-May-2024

    Summary

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    Official Symbol
    SerRSprovided by FlyBase
    Official Full Name
    Seryl-tRNA synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031497
    Locus tag
    Dmel_CG17259
    See related
    AllianceGenome:FB:FBgn0031497
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17259; Dmel\CG17259; DmSRS1
    Summary
    Enables ATP binding activity. Predicted to be involved in seryl-tRNA aminoacylation. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human SARS1 (seryl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See SerRS in Genome Data Viewer
    Location:
    23C5-23C5; 2-8 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3035493..3037403, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3035493..3037403, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44147 Neighboring gene beta4GalNAcTB pilot Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene cornichon related Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New aminoacyl-tRNA synthetase-like protein in insecta with an essential mitochondrial function. Guitart T, et al. J Biol Chem, 2010 Dec 3. PMID 20870726, Free PMC Article
    2. Mitochondrial Protein Synthesis and mtDNA Levels Coordinated through an Aminoacyl-tRNA Synthetase Subunit. Picchioni D, et al. Cell Rep, 2019 Apr 2. PMID 30943413
    3. Small chaperons and autophagy protected neurons from necrotic cell death. Lei Y, et al. Sci Rep, 2017 Jul 18. PMID 28720827, Free PMC Article
    4. A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway. Arsham AM, et al. PLoS One, 2009 Jun 29. PMID 19562034, Free PMC Article
    5. A Genetic Mosaic Screen Reveals Ecdysone-Responsive Genes Regulating Drosophila Oogenesis. Ables ET, et al. G3 (Bethesda), 2016 Aug 9. PMID 27226164, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in seryl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in seryl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in seryl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Seryl-tRNA synthetase
    Names
    CG17259-PA
    CG17259-PB
    SerRS-PA
    SerRS-PB
    seryl-tRNA synthetase
    NP_001259982.1
    NP_608743.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3035493..3037403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134899.3 → NP_608743.2  Seryl-tRNA synthetase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608743.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQL1
      Related
      FBpp0077351
      Conserved Domains (3) summary
      PLN02678
      Location:3 → 476
      PLN02678; seryl-tRNA synthetase
      cd00770
      Location:153 → 461
      SerRS_core; Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound ...
      pfam02403
      Location:3 → 111
      Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

    2. NM_001273053.1 → NP_001259982.1  Seryl-tRNA synthetase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259982.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQL1
      Conserved Domains (3) summary
      PLN02678
      Location:3 → 476
      PLN02678; seryl-tRNA synthetase
      cd00770
      Location:153 → 461
      SerRS_core; Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound ...
      pfam02403
      Location:3 → 111
      Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95TC0 Q95TC0
    Q9VQL1 Q9VQL1

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