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    ATPsynbetaL ATP synthase, beta subunit-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39761, updated on 10-May-2024

    Summary

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    Official Symbol
    ATPsynbetaLprovided by FlyBase
    Official Full Name
    ATP synthase, beta subunit-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036568
    Locus tag
    Dmel_CG5389
    See related
    AllianceGenome:FB:FBgn0036568
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ATPB; ATPsyn-betalike; CG5389; Dmel\CG5389; ms(3)72Dt
    Summary
    Predicted to enable ATP binding activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Involved in determination of adult lifespan; regulation of proton transport; and spermatid differentiation. Predicted to be part of mitochondrial proton-transporting ATP synthase, catalytic core. Is expressed in adult head; organism; and spermatozoon. Orthologous to human ATP5F1B (ATP synthase F1 subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See ATPsynbetaL in Genome Data Viewer
    Location:
    72D5-72D6; 3-44 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16097834..16100088)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16090934..16093188)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Chloride channel-c Neighboring gene uncharacterized protein Neighboring gene Isoleucyl-tRNA synthetase, mitochondrial Neighboring gene Integrator 9 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Perturbation of mitochondrial complex V alters the response to dietary restriction in Drosophila. Bahadorani S, et al. Aging Cell, 2010 Feb. PMID 19968629, Free PMC Article
    2. Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain. Copeland JM, et al. Curr Biol, 2009 Oct 13. PMID 19747824
    3. Single-cell transcriptome sequencing reveals Wolbachia-mediated modification in early stages of Drosophila spermatogenesis. Dou W, et al. Proc Biol Sci, 2023 Jan 11. PMID 36629101, Free PMC Article
    4. ATP synthase F(1) subunits recruited to centromeres by CENP-A are required for male meiosis. Collins CM, et al. Nat Commun, 2018 Jul 13. PMID 30006572, Free PMC Article
    5. Time-restricted feeding attenuates age-related cardiac decline in Drosophila. Gill S, et al. Science, 2015 Mar 13. PMID 25766238, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton-transporting ATP synthase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven ATP synthesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of proton transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mitochondrial proton-transporting ATP synthase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial proton-transporting ATP synthase, catalytic core ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of proton-transporting ATP synthase complex, catalytic core F(1) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proton-transporting ATP synthase complex, catalytic core F(1) IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase, beta subunit-like
    Names
    ATP synthase beta chain
    ATPsynbetaL-PA
    CG5389-PA
    male sterile (3) 72Dt

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16097834..16100088
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140579.2 → NP_648836.2  ATP synthase, beta subunit-like [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648836.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T4C4, Q9VUY3
      Related
      FBpp0075203
      Conserved Domains (4) summary
      PRK09280
      Location:103 → 568
      PRK09280; F0F1 ATP synthase subunit beta; Validated
      cd01133
      Location:175 → 454
      F1-ATPase_beta; F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a ...
      pfam00306
      Location:462 → 571
      ATP-synt_ab_C; ATP synthase alpha/beta chain, C terminal domain
      pfam02874
      Location:106 → 173
      ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T4C4 Q8T4C4

    Gene LinkOut

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