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    Plekhm2 pleckstrin homology and RUN domain containing M2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313667, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Plekhm2provided by RGD
    Official Full Name
    pleckstrin homology and RUN domain containing M2provided by RGD
    Primary source
    RGD:1307005
    See related
    Ensembl:ENSRNOG00000012163 AllianceGenome:RGD:1307005
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable kinesin binding activity. Predicted to be involved in several processes, including lysosome localization; natural killer cell mediated cytotoxicity; and positive regulation of membrane tubulation. Predicted to be located in lysosomal membrane. Predicted to be active in endosome membrane. Orthologous to human PLEKHM2 (pleckstrin homology and RUN domain containing M2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 112.9), Brain (RPKM 91.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plekhm2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (159222620..159261666, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (153939582..153978625, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (160182556..160219770, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487029 Neighboring gene solute carrier family 25, member 34 Neighboring gene transmembrane protein 82 Neighboring gene DNA damage inducible 1 homolog 2 Neighboring gene agmatinase Neighboring gene DnaJ heat shock protein family (Hsp40) member C16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The intracellular fate of Salmonella depends on the recruitment of kinesin. Boucrot E, et al. Science, 2005 May 20. PMID 15905402
    2. Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation. Ohlson MB, et al. Cell Host Microbe, 2008 Nov 13. PMID 18996344, Free PMC Article
    3. The Salmonella virulence protein SifA is a G protein antagonist. Jackson LK, et al. Proc Natl Acad Sci U S A, 2008 Sep 16. PMID 18787122, Free PMC Article
    4. BORC, a multisubunit complex that regulates lysosome positioning. Pu J, et al. Dev Cell, 2015 Apr 20. PMID 25898167, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables kinesin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lysosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lysosome localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family M member 2
    Names
    pleckstrin homology domain containing, family M (with RUN domain) member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191767.1 → NP_001178696.1  pleckstrin homology domain-containing family M member 2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6GI53, D4A932
      Related
      ENSRNOP00000016333.5, ENSRNOT00000016333.8
      Conserved Domains (3) summary
      smart00593
      Location:93 → 156
      RUN; domain involved in Ras-like GTPase signaling
      cd13309
      Location:785 → 887
      PH_SKIP; SifA and kinesin-interacting protein Pleckstrin homology (PH) domain
      pfam00169
      Location:784 → 885
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      159222620..159261666 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110081.2 → XP_038966009.1  pleckstrin homology domain-containing family M member 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4P1, A0A8I6GI53
      Related
      ENSRNOP00000087716.1
      Conserved Domains (3) summary
      smart00593
      Location:93 → 156
      RUN; domain involved in Ras-like GTPase signaling
      PHA03247
      Location:389 → 552
      PHA03247; large tegument protein UL36; Provisional
      cd13309
      Location:765 → 867
      PH_SKIP; SifA and kinesin-interacting protein Pleckstrin homology (PH) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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