Ina internexin neuronal intermediate filament protein, alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Inaprovided by RGD
Official Full Name: internexin neuronal intermediate filament protein, alphaprovided by RGD
Primary source: RGD:2911
See related: Ensembl:ENSRNOG00000020248 AllianceGenome:RGD:2911
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nf66; Inexa; Intlaa; alpha-Inx
Summary: Predicted to be a structural constituent of postsynaptic actin cytoskeleton and structural constituent of postsynaptic intermediate filament cytoskeleton. Involved in tissue regeneration. Is active in glutamatergic synapse and postsynaptic intermediate filament cytoskeleton. Orthologous to human INA (internexin neuronal intermediate filament protein alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 171.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (255838129..255849680)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (245896775..245908330)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (266782835..266794389)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Recombinant rat alpha-internexin coassembles with all three neurofilament proteins into a single network of filaments in quadruple-transfected SW13vim(-) mouse cells.
Title: Alpha-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS.
Alpha-internexin immunoreactive neurites were localized to plaques densely packed with beta-amyloid fibrils in preclinical AD cases, indicating that certain plaques may cause structural injury or impediment of local axonal transport.
Title: alpha-Internexin immunoreactivity reflects variable neuronal vulnerability in Alzheimer's disease and supports the role of the beta-amyloid plaques in inducing neuronal injury.
alpha-internexin plays an important role in neurite outgrowth and regulates the expression of other neurofilaments during neuronal development
Title: Overexpression of neuronal intermediate filament protein alpha-internexin in PC12 cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141537 (e-PCR)
- UniSTS:223531

RH134251 (e-PCR)
- UniSTS:217533

D1Arb46 (e-PCR), detects polymorphism
- UniSTS:227015

D1Mgh13 (e-PCR)
- UniSTS:227019

RH142424 (e-PCR)
- UniSTS:231671

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of postsynaptic intermediate filament cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of postsynaptic intermediate filament cytoskeleton	IEA Inferred from Electronic Annotation more info
enables structural constituent of postsynaptic intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intermediate filament cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neurofilament cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neurofilament cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic intermediate filament cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in substantia nigra development	ISO Inferred from Sequence Orthology more info	PubMed
involved_in tissue regeneration	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic ribonucleoprotein granule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in intermediate filament	IBA Inferred from Biological aspect of Ancestor more info
located_in neurofilament	IEA Inferred from Electronic Annotation more info
located_in neurofilament	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic intermediate filament cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic intermediate filament cytoskeleton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: alpha-internexin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019128.5 → NP_062001.2 alpha-internexin

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P23565

UniProtKB/TrEMBL

A6JHP2, G3V8Q2

Related

ENSRNOP00000027417.5, ENSRNOT00000027417.7

Conserved Domains (2) summary

pfam00038
Location:93 → 406

Filament; Intermediate filament protein

pfam04732
Location:10 → 92

Filament_head; Intermediate filament head (DNA binding) region