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    Tspan6 tetraspanin 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302313, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tspan6provided by RGD
    Official Full Name
    tetraspanin 6provided by RGD
    Primary source
    RGD:1560160
    See related
    Ensembl:ENSRNOG00000003786 AllianceGenome:RGD:1560160
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in negative regulation of NIK/NF-kappaB signaling; negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway; and positive regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to be integral component of plasma membrane. Orthologous to human TSPAN6 (tetraspanin 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 652.9), Lung (RPKM 120.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tspan6 in Genome Data Viewer
    Location:
    Xq32
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (101385686..101395371, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (97092394..97099659, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (104719930..104729606, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene tenomodulin Neighboring gene sushi-repeat-containing protein, X-linked 2 Neighboring gene synaptotagmin-like 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tetraspanin 6 (TSPAN6) negatively regulates retinoic acid-inducible gene I-like receptor-mediated immune signaling in a ubiquitination-dependent manner. Wang Y, et al. J Biol Chem, 2012 Oct 5. PMID 22908223, Free PMC Article
    2. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Matsuda A, et al. Oncogene, 2003 May 22. PMID 12761501
    3. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
    4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cytoplasmic pattern recognition receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin-6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100672.1 → NP_001094142.1  tetraspanin-6

      See identical proteins and their annotated locations for NP_001094142.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158651
      UniProtKB/TrEMBL
      A0A8I6A7Q5, B0BN20, F7ESS4
      Related
      ENSRNOP00000088359.1, ENSRNOT00000119163.1
      Conserved Domains (1) summary
      pfam00335
      Location:17 → 233
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      101385686..101395371 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008773408.4 → XP_008771630.1  tetraspanin-6 isoform X2

      Conserved Domains (2) summary
      cd03161
      Location:24 → 121
      TM4SF2_6_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:1 → 149
      Tetraspannin; Tetraspanin family

    2. XM_063279888.1 → XP_063135958.1  tetraspanin-6 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7Q5, B0BN20
    Nucleotide Protein Strain
    Heading Accession and Version

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