Mfap5 microfibril associated protein 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mfap5provided by RGD
Official Full Name: microfibril associated protein 5provided by RGD
Primary source: RGD:1307919
See related: Ensembl:ENSRNOG00000015505 AllianceGenome:RGD:1307919
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in definitive hemopoiesis and embryonic eye morphogenesis. Predicted to act upstream of or within supramolecular fiber organization. Predicted to be located in extracellular matrix. Predicted to be active in microfibril. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Orthologous to human MFAP5 (microfibril associated protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 228.5), Heart (RPKM 173.5) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (157399919..157422448)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (155727925..155750458)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (155313671..155336228)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tricellulin, alpha-Catenin and Microfibrillar-Associated Protein 5 Exhibit Concomitantly Altered Immunosignals along with Vascular, Extracellular and Cytoskeletal Elements after Experimental Focal Cerebral Ischemia.
Title: Tricellulin, α-Catenin and Microfibrillar-Associated Protein 5 Exhibit Concomitantly Altered Immunosignals along with Vascular, Extracellular and Cytoskeletal Elements after Experimental Focal Cerebral Ischemia.

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in definitive hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic eye morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within supramolecular fiber organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in microfibril	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: microfibrillar-associated protein 5

Names: microfibrillar associated protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108644.1 → NP_001102114.1 microfibrillar-associated protein 5 precursor

See identical proteins and their annotated locations for NP_001102114.1

Status: PROVISIONAL

Source sequence(s)

CH473964

UniProtKB/TrEMBL

A0A8I6GG30, A6ILE8, A6ILE9, D3ZJB1

Related

ENSRNOP00000020812.5, ENSRNOT00000020812.7

Conserved Domains (1) summary

pfam05507
Location:4 → 131

MAGP; Microfibril-associated glycoprotein (MAGP)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

157399919..157422448

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017592703.3 → XP_017448192.1 microfibrillar-associated protein 5 isoform X1

UniProtKB/TrEMBL

A0A8I6GG30, A6ILE8, A6ILE9, D3ZJB1

Conserved Domains (1) summary

pfam05507
Location:4 → 131

MAGP; Microfibril-associated glycoprotein (MAGP)