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    Recql RecQ like helicase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312824, updated on 20-Apr-2024

    Summary

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    Official Symbol
    Recqlprovided by RGD
    Official Full Name
    RecQ like helicaseprovided by RGD
    Primary source
    RGD:1311071
    See related
    Ensembl:ENSRNOG00000012602 AllianceGenome:RGD:1311071
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 3'-5' DNA helicase activity; ATP-dependent DNA/DNA annealing activity; and four-way junction helicase activity. Predicted to be involved in DNA unwinding involved in DNA replication and double-strand break repair via homologous recombination. Predicted to be located in nucleoplasm. Predicted to be active in chromosome and cytoplasm. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and pancreatic cancer. Orthologous to human RECQL (RecQ like helicase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 594.1), Lung (RPKM 133.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    4q44
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (177039351..177063968, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (175308337..175332965, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (176581892..176606520, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family, member 1A5 Neighboring gene islet amyloid polypeptide Neighboring gene uncharacterized LOC102549024 Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene golgi transport 1B Neighboring gene spexin hormone

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Anticancer activity of RecQL1 helicase siRNA in mouse xenograft models. Futami K, et al. Cancer Sci, 2008 Jun. PMID 18422747
    2. Single nucleotide polymorphism in RECQL and survival in resectable pancreatic adenocarcinoma. Cotton RT, et al. HPB (Oxford), 2009 Aug. PMID 19768149, Free PMC Article
    3. Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4. Xu X, et al. EMBO J, 2009 Mar 4. PMID 19177149, Free PMC Article
    4. Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survival. Li D, et al. Cancer Res, 2006 Mar 15. PMID 16540687, Free PMC Article
    5. The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. Kume T, et al. Genes Dev, 2001 Sep 15. PMID 11562355, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3'-5' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3'-5' DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA/DNA annealing activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA/DNA annealing activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables four-way junction helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in replication fork processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent DNA helicase Q1
    Names
    DNA 3'-5' helicase Q1
    DNA-dependent ATPase Q1
    RecQ helicase-like
    RecQ protein-like (DNA helicase Q1-like)
    recQ protein-like 1
    NP_001012098.1
    XP_006237679.1
    XP_006237680.1
    XP_006237681.1
    XP_006237682.1
    XP_038963628.1
    XP_038963629.1
    XP_038963630.1
    XP_038963631.1
    XP_063142235.1
    XP_063142236.1
    XP_063142237.1
    XP_063142239.1
    XP_063142240.1
    XP_063142241.1
    XP_063142242.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012098.1 → NP_001012098.1  ATP-dependent DNA helicase Q1

      See identical proteins and their annotated locations for NP_001012098.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079026
      UniProtKB/Swiss-Prot
      Q6AYJ1
      UniProtKB/TrEMBL
      A0A8I6A2E6, A6IMT6
      Related
      ENSRNOP00000060671.1, ENSRNOT00000065576.3
      Conserved Domains (1) summary
      TIGR00614
      Location:82 → 543
      recQ_fam; ATP-dependent DNA helicase, RecQ family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      177039351..177063968 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286166.1 → XP_063142236.1  ATP-dependent DNA helicase Q1 isoform X2

    2. XM_063286171.1 → XP_063142241.1  ATP-dependent DNA helicase Q1 isoform X4

    3. XM_039107702.2 → XP_038963630.1  ATP-dependent DNA helicase Q1 isoform X3

      UniProtKB/Swiss-Prot
      Q6AYJ1
      UniProtKB/TrEMBL
      A0A8I6A2E6, A6IMT6
      Related
      ENSRNOP00000085782.1
      Conserved Domains (1) summary
      TIGR00614
      Location:82 → 543
      recQ_fam; ATP-dependent DNA helicase, RecQ family

    4. XM_006237619.5 → XP_006237681.1  ATP-dependent DNA helicase Q1 isoform X1

      See identical proteins and their annotated locations for XP_006237681.1

      UniProtKB/TrEMBL
      A0A8I5Y8C0, A0A8I6A2E6, A6IMT7
      Conserved Domains (1) summary
      TIGR00614
      Location:82 → 543
      recQ_fam; ATP-dependent DNA helicase, RecQ family

    5. XM_063286167.1 → XP_063142237.1  ATP-dependent DNA helicase Q1 isoform X3

      UniProtKB/Swiss-Prot
      Q6AYJ1
      UniProtKB/TrEMBL
      A6IMT6

    6. XM_006237617.4 → XP_006237679.1  ATP-dependent DNA helicase Q1 isoform X1

      See identical proteins and their annotated locations for XP_006237679.1

      UniProtKB/TrEMBL
      A0A8I5Y8C0, A0A8I6A2E6, A6IMT7
      Related
      ENSRNOP00000077921.1
      Conserved Domains (1) summary
      TIGR00614
      Location:82 → 543
      recQ_fam; ATP-dependent DNA helicase, RecQ family

    7. XM_063286165.1 → XP_063142235.1  ATP-dependent DNA helicase Q1 isoform X2

    8. XM_063286170.1 → XP_063142240.1  ATP-dependent DNA helicase Q1 isoform X4

    9. XM_039107703.2 → XP_038963631.1  ATP-dependent DNA helicase Q1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A2E6
      Conserved Domains (1) summary
      TIGR00614
      Location:82 → 543
      recQ_fam; ATP-dependent DNA helicase, RecQ family

    10. XM_039107701.2 → XP_038963629.1  ATP-dependent DNA helicase Q1 isoform X3

      UniProtKB/Swiss-Prot
      Q6AYJ1
      UniProtKB/TrEMBL
      A0A8I6A2E6, A6IMT6
      Conserved Domains (1) summary
      TIGR00614
      Location:82 → 543
      recQ_fam; ATP-dependent DNA helicase, RecQ family

    11. XM_006237618.2 → XP_006237680.1  ATP-dependent DNA helicase Q1 isoform X1

      See identical proteins and their annotated locations for XP_006237680.1

      UniProtKB/TrEMBL
      A0A8I5Y8C0, A0A8I6A2E6, A6IMT7
      Conserved Domains (1) summary
      TIGR00614
      Location:82 → 543
      recQ_fam; ATP-dependent DNA helicase, RecQ family

    12. XM_006237620.5 → XP_006237682.1  ATP-dependent DNA helicase Q1 isoform X1

      See identical proteins and their annotated locations for XP_006237682.1

      UniProtKB/TrEMBL
      A0A8I5Y8C0, A0A8I6A2E6, A6IMT7
      Conserved Domains (1) summary
      TIGR00614
      Location:82 → 543
      recQ_fam; ATP-dependent DNA helicase, RecQ family

    13. XM_039107700.2 → XP_038963628.1  ATP-dependent DNA helicase Q1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A2E6
      Conserved Domains (1) summary
      TIGR00614
      Location:82 → 543
      recQ_fam; ATP-dependent DNA helicase, RecQ family

    14. XM_063286169.1 → XP_063142239.1  ATP-dependent DNA helicase Q1 isoform X3

      UniProtKB/Swiss-Prot
      Q6AYJ1
      UniProtKB/TrEMBL
      A6IMT6

    15. XM_063286172.1 → XP_063142242.1  ATP-dependent DNA helicase Q1 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYJ1.1 GenPept UniProtKB/Swiss-Prot:Q6AYJ1

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