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    Ten1 TEN1 subunit of CST complex [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360664, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ten1provided by RGD
    Official Full Name
    TEN1 subunit of CST complexprovided by RGD
    Primary source
    RGD:1311078
    See related
    Ensembl:ENSRNOG00000060307 AllianceGenome:RGD:1311078
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311078
    Summary
    Predicted to enable telomerase inhibitor activity and telomeric DNA binding activity. Predicted to be involved in negative regulation of telomere maintenance via telomerase. Predicted to be located in chromosome, telomeric region and nucleoplasm. Predicted to be part of CST complex. Orthologous to human TEN1 (TEN1 subunit of CST complex). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 55.0), Lung (RPKM 53.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ten1 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (101930212..101951932)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (101431328..101455105)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (105073077..105095094)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene Fas binding factor 1 Neighboring gene small Cajal body-specific RNA 4 Neighboring gene acyl-CoA oxidase 1 Neighboring gene uncharacterized LOC134480905 Neighboring gene envoplakin Neighboring gene uncharacterized LOC120095213 Neighboring gene signal recognition particle 68

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The human CST complex is a terminator of telomerase activity. Chen LY, et al. Nature, 2012 Aug 23. PMID 22763445
    2. RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway. Miyake Y, et al. Mol Cell, 2009 Oct 23. PMID 19854130
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables telomerase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of telomere maintenance via telomerase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of CST complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CST complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CST complex subunit TEN1
    Names
    TEN1 CST complex subunit
    TEN1 telomerase capping complex subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108307.1 → NP_001101777.1  CST complex subunit TEN1

      See identical proteins and their annotated locations for NP_001101777.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A0A0G2K213, A6HKU9
      Related
      ENSRNOP00000072065.2, ENSRNOT00000083022.2
      Conserved Domains (1) summary
      pfam15490
      Location:2 → 118
      Ten1_2; Telomere-capping, CST complex subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      101930212..101951932
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086432.2 → XP_038942360.1  CST complex subunit TEN1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K213, A6HKU9
      Conserved Domains (1) summary
      pfam15490
      Location:2 → 118
      Ten1_2; Telomere-capping, CST complex subunit

    2. XM_039086431.2 → XP_038942359.1  CST complex subunit TEN1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K213, A6HKU9
      Conserved Domains (1) summary
      pfam15490
      Location:2 → 118
      Ten1_2; Telomere-capping, CST complex subunit
    Nucleotide Protein Strain
    Heading Accession and Version

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