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    Nudt7 nudix hydrolase 7 [ Mus musculus (house mouse) ]

    Gene ID: 67528, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Nudt7provided by MGI
    Official Full Name
    nudix hydrolase 7provided by MGI
    Primary source
    MGI:MGI:1914778
    See related
    Ensembl:ENSMUSG00000031767 AllianceGenome:MGI:1914778
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1300007B24Rik; 2210404C19Rik
    Summary
    Enables CoA pyrophosphatase activity; magnesium ion binding activity; and snoRNA binding activity. Involved in purine nucleoside bisphosphate catabolic process. Acts upstream of or within brown fat cell differentiation. Located in peroxisome. Orthologous to human NUDT7 (nudix hydrolase 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 27.8), subcutaneous fat pad adult (RPKM 6.0) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nudt7 in Genome Data Viewer
    Location:
    8 E1; 8 60.53 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (114860314..114881471)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (114133574..114154731)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 18 Neighboring gene STARR-seq mESC enhancer starr_22763 Neighboring gene predicted gene, 30107 Neighboring gene STARR-seq mESC enhancer starr_22765 Neighboring gene STARR-positive B cell enhancer ABC_E9028 Neighboring gene STARR-seq mESC enhancer starr_22767 Neighboring gene vesicle amine transport protein 1 like Neighboring gene RIKEN cDNA 4933408N05 gene Neighboring gene predicted gene, 30330 Neighboring gene C-type lectin domain family 3, member a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NUDT7 regulates total hepatic CoA levels and the composition of the intestinal bile acid pool in male mice fed a Western diet. Vickers SD, et al. J Biol Chem, 2023 Jan. PMID 36436558, Free PMC Article
    2. Overexpression of Nudt7 decreases bile acid levels and peroxisomal fatty acid oxidation in the liver. Shumar SA, et al. J Lipid Res, 2019 May. PMID 30846528, Free PMC Article
    3. Dysregulation of the NUDT7-PGAM1 axis is responsible for chondrocyte death during osteoarthritis pathogenesis. Song J, et al. Nat Commun, 2018 Aug 24. PMID 30143643, Free PMC Article
    4. Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform. Shumar SA, et al. J Biol Chem, 2018 Mar 16. PMID 29378847, Free PMC Article
    5. The nudix hydrolase 7 is an Acyl-CoA diphosphatase involved in regulating peroxisomal coenzyme A homeostasis. Reilly SJ, et al. J Biochem, 2008 Nov. PMID 18799520

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upregulated FOXM1 stimulates chondrocyte senescence in Acot12[-/-]Nudt7[-/-] double knockout mice.
      Title: Upregulated FOXM1 stimulates chondrocyte senescence in Acot12(-/-)Nudt7(-/-) double knockout mice.
    2. NUDT7 regulates total hepatic CoA levels and the composition of the intestinal bile acid pool in male mice fed a Western diet.
      Title: NUDT7 regulates total hepatic CoA levels and the composition of the intestinal bile acid pool in male mice fed a Western diet.
    3. The modulation of Nudt7 activity could contribute to the regulation of the peroxisomal CoA pool and peroxisomal lipid metabolism.
      Title: Overexpression of Nudt7 decreases bile acid levels and peroxisomal fatty acid oxidation in the liver.
    4. Data suggest that NUDT7alpha function is tightly linked to peroxisomal CoASH/acyl-CoA homeostasis.
      Title: The nudix hydrolase 7 is an Acyl-CoA diphosphatase involved in regulating peroxisomal coenzyme A homeostasis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables coenzyme A diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables coenzyme A diphosphatase activity TAS
    Traceable Author Statement
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables snoRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within acetyl-CoA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in acetyl-CoA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within brown fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in butyryl-CoA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in coenzyme A catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within coenzyme A catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in coenzyme A catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in malonyl-CoA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in medium-chain fatty-acyl-CoA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleoside diphosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in propionyl-CoA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in propionyl-CoA metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in succinyl-CoA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in peroxisomal matrix TAS
    Traceable Author Statement
    more info
    		  
    is_active_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peroxisomal coenzyme A diphosphatase NUDT7
    Names
    coenzyme A diphosphatase
    nucleoside diphosphate-linked moiety X motif 7
    nudix (nucleoside diphosphate linked moiety X)-type motif 7
    nudix motif 7
    NP_001277110.1
    NP_001277111.1
    NP_001363956.1
    NP_077757.2
    NP_077766.3
    XP_011246793.1
    XP_017168434.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290181.1 → NP_001277110.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform 4

      See identical proteins and their annotated locations for NP_001277110.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AC121999, AF338424, AK004924
      Consensus CDS
      CCDS80935.1
      UniProtKB/Swiss-Prot
      Q99P30
      Related
      ENSMUSP00000104737.2, ENSMUST00000109109.8
      Conserved Domains (1) summary
      cd03426
      Location:65 → 225
      CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

    2. NM_001290182.1 → NP_001277111.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks a 3' exon but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (5) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC121999, AK008824, BC033046
      Consensus CDS
      CCDS80934.1
      UniProtKB/Swiss-Prot
      Q99P30
      Related
      ENSMUSP00000116868.2, ENSMUST00000134593.2
      Conserved Domains (1) summary
      cd03426
      Location:41 → 121
      CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

    3. NM_001377027.1 → NP_001363956.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC121999
      Conserved Domains (1) summary
      cd03426
      Location:41 → 114
      CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

    4. NM_024437.4 → NP_077757.2  peroxisomal coenzyme A diphosphatase NUDT7 isoform 1

      See identical proteins and their annotated locations for NP_077757.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC121999, AF338424, AK004924
      Consensus CDS
      CCDS22687.1
      UniProtKB/Swiss-Prot
      Q6IS65, Q8BU08, Q8K260, Q99P30, Q9D0Q3, Q9DBI9
      Related
      ENSMUSP00000073213.6, ENSMUST00000073521.12
      Conserved Domains (1) summary
      cd03426
      Location:41 → 201
      CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

    5. NM_024446.5 → NP_077766.3  peroxisomal coenzyme A diphosphatase NUDT7 isoform 2

      See identical proteins and their annotated locations for NP_077766.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AC121999, AF338424, AK004924, AK011172
      Consensus CDS
      CCDS22688.2
      UniProtKB/Swiss-Prot
      Q99P30
      Related
      ENSMUSP00000114598.2, ENSMUST00000147605.8
      Conserved Domains (1) summary
      cd03426
      Location:41 → 181
      CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

    RNA

    1. NR_165049.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121999
      Related
      ENSMUST00000066514.13

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      114860314..114881471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248491.3 → XP_011246793.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform X2

      Conserved Domains (1) summary
      cd03426
      Location:65 → 138
      CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

    2. XM_017312945.1 → XP_017168434.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform X1

      Conserved Domains (1) summary
      cd03426
      Location:65 → 205
      CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001290180.1: Suppressed sequence

      Description
      NM_001290180.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99P30.2 GenPept UniProtKB/Swiss-Prot:Q99P30

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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