Timm17a translocase of inner mitochondrial membrane 17A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Timm17aprovided by RGD
Official Full Name: translocase of inner mitochondrial membrane 17Aprovided by RGD
Primary source: RGD:3862
See related: Ensembl:ENSRNOG00000007040 AllianceGenome:RGD:3862
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tim17; Timm17
Summary: Enables enzyme binding activity. Involved in positive regulation of protein processing. Located in mitochondrial inner membrane. Orthologous to human TIMM17A (translocase of inner mitochondrial membrane 17A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 965.4), Muscle (RPKM 907.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (49282918..49296363, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (46731117..46742604, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (52124641..52136127, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH136499 (e-PCR)
- UniSTS:210482

D13Hmgc62 (e-PCR)
- UniSTS:519029

RH127788 (e-PCR)
- UniSTS:211098

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to protein transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into mitochondrial matrix	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of TIM23 mitochondrial import inner membrane translocase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TIM23 mitochondrial import inner membrane translocase complex	IEA Inferred from Electronic Annotation more info
part_of TIM23 mitochondrial import inner membrane translocase complex	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial import inner membrane translocase subunit Tim17-A

Names: inner membrane preprotein translocase Tim17a; translocase of inner mitochondrial membrane 17 homolog A; translocator of inner mitochondrial membrane 17 kDa, a; translocator of inner mitochondrial membrane 17a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019351.2 → NP_062224.1 mitochondrial import inner membrane translocase subunit Tim17-A

See identical proteins and their annotated locations for NP_062224.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

O35092

UniProtKB/TrEMBL

A0A8I6ANA6, A6ICE7

Related

ENSRNOP00000094804.1, ENSRNOT00000099219.1

Conserved Domains (1) summary

TIGR00980
Location:1 → 171

3a0801so1tim17; mitochondrial import inner membrane translocase subunit tim17

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

49282918..49296363 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272562.1 → XP_063128632.1 mitochondrial import inner membrane translocase subunit Tim17-A isoform X1

UniProtKB/Swiss-Prot

O35092

UniProtKB/TrEMBL

A6ICE7