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    Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291103, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Uqcrfs1provided by RGD
    Official Full Name
    ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1provided by RGD
    Primary source
    RGD:628838
    See related
    Ensembl:ENSRNOG00000018281 AllianceGenome:RGD:628838
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LRRGT00195
    Summary
    Predicted to enable oxidoreductase activity. Involved in response to antibiotic; response to hormone; and response to xenobiotic stimulus. Located in mitochondrial membrane. Part of mitochondrial respiratory chain complex III. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency. Orthologous to several human genes including UQCRFS1 (ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 5521.8), Muscle (RPKM 4150.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Uqcrfs1 in Genome Data Viewer
    Location:
    17p12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (34173787..34190952)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (33977908..33982478)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (35677984..35682262)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 22 Neighboring gene uncharacterized LOC108348556 Neighboring gene glycogenin 1, pseudogene 1 Neighboring gene angiotensin II receptor, type 1a Neighboring gene membrane bound O-acyltransferase domain containing 1 Neighboring gene non-POU domain containing, octamer-binding, pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dephosphorylation of the Rieske iron-sulfur protein after induction of the mitochondrial permeability transition. He L, et al. Biochem Biophys Res Commun, 2005 Sep 2. PMID 16023995
    2. Proteomic identification of the involvement of the mitochondrial rieske protein in epilepsy. Junker H, et al. Epilepsia, 2005 Mar. PMID 15730530
    3. Molecular mechanisms of doxorubicin-induced cardiomyopathy. Selective suppression of Reiske iron-sulfur protein, ADP/ATP translocase, and phosphofructokinase genes is associated with ATP depletion in rat cardiomyocytes. Jeyaseelan R, et al. J Biol Chem, 1997 Feb 28. PMID 9038198
    4. Thyroid hormone regulation of nuclear-encoded mitochondrial inner membrane polypeptides of the liver. Joste V, et al. Eur J Biochem, 1989 Sep 1. PMID 2776768
    5. Cloning and sequence analysis of a cDNA encoding the Rieske iron-sulfur protein of rat mitochondrial cytochrome bc1 complex. Nishikimi M, et al. Biochem Biophys Res Commun, 1989 Feb 28. PMID 2538119

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mass spectrometric characterization of ubiquinol-cytochrome c reductase; ten of the 11 polypeptides present in this complex were detected directly by MALDI-TOFMS following electroelution of the active complex
      Title: Mass spectrometric characterization of mitochondrial electron transport complexes: subunits of the rat heart ubiquinol-cytochrome c reductase.
    2. Conformational changes from phosphorylation & dephosphorylation of RISP may thus regulate mitochondrial permeability transition pore formation & conductance.
      Title: Dephosphorylation of the Rieske iron-sulfur protein after induction of the mitochondrial permeability transition.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105530

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquinol-cytochrome-c reductase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in respiratory electron transport chain ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in respiratory electron transport chain ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to hormone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial respiratory chain complex III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial respiratory chain complex III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial respiratory chain complex III ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial respiratory chain complex IV ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of respiratory chain complex III TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome b-c1 complex subunit Rieske, mitochondrial
    Names
    RISP
    Rieske protein UQCRFS1
    complex III subunit 5
    cytochrome b-c1 complex subunit 5
    liver regeneration-related protein LRRGT00195
    rieske iron-sulfur protein
    ubiquinol-cytochrome c reductase iron-sulfur subunit
    NP_001008888.1
    XP_063132254.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008888.1 → NP_001008888.1  cytochrome b-c1 complex subunit Rieske, mitochondrial

      See identical proteins and their annotated locations for NP_001008888.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085339
      UniProtKB/Swiss-Prot
      P20788, Q6QI13
      UniProtKB/TrEMBL
      A6J7M2, A6J7M3
      Related
      ENSRNOP00000024609.4, ENSRNOT00000024609.7
      Conserved Domains (4) summary
      cd03470
      Location:151 → 274
      Rieske_cytochrome_bc1; Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including ...
      TIGR01416
      Location:114 → 274
      Rieske_proteo; ubiquinol-cytochrome c reductase, iron-sulfur subunit
      pfam02921
      Location:80 → 145
      UCR_TM; Ubiquinol cytochrome reductase transmembrane region
      pfam09165
      Location:2 → 77
      Ubiq-Cytc-red_N; Ubiquinol-cytochrome c reductase 8 kDa, N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      34173787..34190952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276184.1 → XP_063132254.1  cytochrome b-c1 complex subunit Rieske, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      P20788, Q6QI13
      UniProtKB/TrEMBL
      A6J7M2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20788.2 GenPept UniProtKB/Swiss-Prot:P20788

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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