Slc12a7 solute carrier family 12 member 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc12a7provided by RGD
Official Full Name: solute carrier family 12 member 7provided by RGD
Primary source: RGD:1359672
See related: Ensembl:ENSRNOG00000016372 AllianceGenome:RGD:1359672
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kcc4
Summary: Predicted to enable ammonium transmembrane transporter activity; potassium:chloride symporter activity; and protein kinase binding activity. Involved in cell volume homeostasis. Predicted to be located in plasma membrane. Predicted to be part of protein-containing complex. Orthologous to human SLC12A7 (solute carrier family 12 member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 313.9), Thymus (RPKM 179.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p11

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (31301243..31382825, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (29472692..29554246, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (32086755..32167950, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data are consistent with a role for KCC4 in salt reabsorption of the thick ascending loop of Henle's loop and acid secretion of the collecting duct.
Title: Molecular evidence for a role for K(+)-Cl(-) cotransporters in the kidney.
Kinetic models of Na+-K+-2Cl- costransporter (NKCC2) and K+-Cl- cotransporter (KCC4), two of the key cotransporters of the Henle limb, are fashioned with inclusion of terms representing binding and transport of NH4+.
Title: A mathematical model of rat ascending Henle limb. I. Cotransporter function.
KCC4 and H+,K+-ATPase are the main machineries for basal HCl secretion in the apical canalicular membrane of the resting parietal cell. They also may contribute in part to massive acid secretion in the stimulated state.
Title: Functional association between K+-Cl- cotransporter-4 and H+,K+-ATPase in the apical canalicular membrane of gastric parietal cells.
In the rat brain, KCC4 express in the choroid plexus and the suprachiasmatic nucleus of the hypothalamus.
Title: KCC3 and KCC4 expression in rat adult forebrain.
distribution of KCC1, KCC3a, KCC3b, KCC4, and KCC2 protein and mrna in pancreatic alpha-cells and beta-cells; KCC's make a significant contribution to volume homeostasis only in alpha-cells
Title: Expression of K+-Cl- cotransporters in the alpha-cells of rat endocrine pancreas.

Submit: New GeneRIF Correction

General gene information

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Markers

RH133369 (e-PCR)
- UniSTS:216652

D1Rat9 (e-PCR)
- UniSTS:118626

D1Cebr11 (e-PCR)
- UniSTS:518518

D1Cebr12 (e-PCR)
- UniSTS:518792

RH128389 (e-PCR)
- UniSTS:211697

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ammonium transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables ammonium transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables chloride:monoatomic cation symporter activity	IEA Inferred from Electronic Annotation more info
enables potassium:chloride symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium:chloride symporter activity	IEA Inferred from Electronic Annotation more info
enables potassium:chloride symporter activity	ISO Inferred from Sequence Orthology more info
enables potassium:chloride symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium:chloride symporter activity	TAS Traceable Author Statement more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ammonium import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in ammonium import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in cell volume homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell volume homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier family 12 member 7

Names: K-Cl cotransporter 4; K-Cl cotransporter KCC4; electroneutral potassium-chloride cotransporter 4; furosemide-sensitive KCl cotransporter 4; solute carrier family 12 (potassium/chloride transporter), member 7; solute carrier family 12 (potassium/chloride transporters), member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013144.2 → NP_001013162.2 solute carrier family 12 member 7

See identical proteins and their annotated locations for NP_001013162.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q5RK27, Q6T7Y5, Q6TUA1, Q6TUA2

UniProtKB/TrEMBL

A0A8L2QBZ1, A6JUW3

Related

ENSRNOP00000022635.5, ENSRNOT00000022635.8

Conserved Domains (2) summary

TIGR00930
Location:45 → 1083

2a30; K-Cl cotransporter

pfam03522
Location:709 → 1083

SLC12; Solute carrier family 12

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

31301243..31382825 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006227789.5 → XP_006227851.1 solute carrier family 12 member 7 isoform X3

UniProtKB/TrEMBL

A0A0G2K8S1

Conserved Domains (2) summary

TIGR00930
Location:77 → 1115

2a30; K-Cl cotransporter

pfam03522
Location:741 → 1115

SLC12; Solute carrier family 12
XM_063288386.1 → XP_063144456.1 solute carrier family 12 member 7 isoform X1
XM_063288392.1 → XP_063144462.1 solute carrier family 12 member 7 isoform X2