Ghitm growth hormone inducible transmembrane protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ghitmprovided by RGD
Official Full Name: growth hormone inducible transmembrane proteinprovided by RGD
Primary source: RGD:1359301
See related: Ensembl:ENSRNOG00000013961 AllianceGenome:RGD:1359301
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MICS1
Summary: Predicted to be involved in inner mitochondrial membrane organization and negative regulation of release of cytochrome c from mitochondria. Predicted to be located in mitochondrion. Predicted to be integral component of mitochondrial inner membrane. Orthologous to human GHITM (growth hormone inducible transmembrane protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 1462.3), Adrenal (RPKM 1014.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (12907062..12918149, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (12885551..12897887, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (14370269..14382647, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH141018 (e-PCR)
- UniSTS:223018

AA799642 (e-PCR)
- UniSTS:260594

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables calcium:proton antiporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in calcium export from the mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in calcium export from the mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in inner mitochondrial membrane organization	ISO Inferred from Sequence Orthology more info
involved_in inner mitochondrial membrane organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial calcium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: growth hormone-inducible transmembrane protein

Names: mitochondrial morphology and cristae structure 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.