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    Zfpm1 zinc finger protein, multitype 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691504, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Zfpm1provided by RGD
    Official Full Name
    zinc finger protein, multitype 1provided by RGD
    Primary source
    RGD:1582810
    See related
    Ensembl:ENSRNOG00000043077 AllianceGenome:RGD:1582810
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription corepressor activity. Predicted to be involved in several processes, including animal organ development; regulation of gene expression; and regulation of myeloid cell differentiation. Predicted to act upstream of or within myeloid cell differentiation and regulation of chemokine production. Predicted to be located in cytoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Orthologous to human ZFPM1 (zinc finger protein, FOG family member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 51.9), Adrenal (RPKM 26.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfpm1 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (67242922..67299149)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (50334352..50391029)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (55094585..55150994)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene Btg3 associated nuclear protein Neighboring gene zinc finger protein 469 Neighboring gene uncharacterized LOC120098606 Neighboring gene motilin receptor Neighboring gene zinc finger CCCH-type containing 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FOG-1-mediated recruitment of NuRD is required for cell lineage re-enforcement during haematopoiesis. Gao Z, et al. EMBO J, 2010 Jan 20. PMID 20010697, Free PMC Article
    2. The suppression of zfpm-1 accelerates the erythropoietic differentiation of human CD34+ cells. Yang HY, et al. Biochem Biophys Res Commun, 2007 Feb 23. PMID 17207461
    3. Zinc finger protein, multitype 1, suppresses human Th2 development via downregulation of IL-4. Kitamura N, et al. Int Arch Allergy Immunol, 2011. PMID 21646796
    4. Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG. Tsang AP, et al. Genes Dev, 1998 Apr 15. PMID 9553047, Free PMC Article
    5. Early retinoic acid-induced F9 teratocarcinoma stem cell gene ERA-1: alternate splicing creates transcripts for a homeobox-containing protein and one lacking the homeobox. LaRosa GJ, et al. Mol Cell Biol, 1988 Sep. PMID 2906112, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in atrial septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in atrioventricular valve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cardiac muscle tissue morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within definitive erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryonic hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in erythrocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within granulocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within homeostasis of number of cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within megakaryocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in megakaryocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within megakaryocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitral valve formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-4 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mast cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in outflow tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in platelet formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within primitive erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of definitive erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tricuspid valve formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ventricular septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein ZFPM1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242627.1 → NP_001229556.1  zinc finger protein ZFPM1

      See identical proteins and their annotated locations for NP_001229556.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I5ZR33, A6IZR2
      Related
      ENSRNOP00000081045.1, ENSRNOT00000111720.1
      Conserved Domains (2) summary
      sd00017
      Location:308 → 327
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:319 → 344
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      67242922..67299149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098006.2 → XP_038953934.1  zinc finger protein ZFPM1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZR33, D4A168
      Related
      ENSRNOP00000061082.4
      Conserved Domains (2) summary
      sd00017
      Location:257 → 290
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd19215
      Location:101 → 209
      PR-SET_ZFPM1; PR-SET domain found in zinc finger protein ZFPM1 and similar proteins

    2. XM_039098007.2 → XP_038953935.1  zinc finger protein ZFPM1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZR33
      Conserved Domains (2) summary
      sd00017
      Location:257 → 290
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd19215
      Location:101 → 209
      PR-SET_ZFPM1; PR-SET domain found in zinc finger protein ZFPM1 and similar proteins

    3. XM_008772649.3 → XP_008770871.1  zinc finger protein ZFPM1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZR33
      Conserved Domains (2) summary
      sd00017
      Location:153 → 172
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:164 → 189
      zf-H2C2_2; Zinc-finger double domain

    4. XM_039098008.2 → XP_038953936.1  zinc finger protein ZFPM1 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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