Iqub IQ motif and ubiquitin domain containing [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Iqubprovided by RGD
Official Full Name: IQ motif and ubiquitin domain containingprovided by RGD
Primary source: RGD:4145674
See related: Ensembl:ENSRNOG00000021729 AllianceGenome:RGD:4145674
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Trs4; RGD1562359
Summary: Predicted to be involved in cilium assembly. Predicted to act upstream of or within smoothened signaling pathway. Predicted to be active in acrosomal vesicle and motile cilium. Orthologous to human IQUB (IQ motif and ubiquitin domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 251.2), Heart (RPKM 49.1) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q22

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (53897336..53962279, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (52931768..52993795, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (51482169..51586881, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggested that Trs4 might be involved in diverse processes of spermiogenesis and/or fertilization through interactions with its multiple binding partners.
Title: Male germ cell-specific protein Trs4 binds to multiple proteins.
findings confirm that the Exo70-TC10 complex mainly targets the NGF-induced Cdc42-dependent activation of N-WASP
Title: An NGF-induced Exo70-TC10 complex locally antagonises Cdc42-mediated activation of N-WASP to modulate neurite outgrowth.
SNX9 interacts with dynamin-1 and N-WASP in presynaptic terminals, where it links actin dynamics and synaptic vesicle endocytosis.
Title: Sorting nexin 9 interacts with dynamin 1 and N-WASP and coordinates synaptic vesicle endocytosis.

Submit: New GeneRIF Correction

General gene information

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Markers

RH132354 (e-PCR)
- UniSTS:215637

RH129536 (e-PCR)
- UniSTS:212838

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	ISS Inferred from Sequence or Structural Similarity more info
involved_in mating	ISO Inferred from Sequence Orthology more info
involved_in mating	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within smoothened signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in 9+2 motile cilium	ISO Inferred from Sequence Orthology more info
located_in 9+2 motile cilium	ISS Inferred from Sequence or Structural Similarity more info
is_active_in acrosomal vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
is_active_in motile cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in motile cilium	ISO Inferred from Sequence Orthology more info
part_of radial spoke	ISO Inferred from Sequence Orthology more info
part_of radial spoke	ISS Inferred from Sequence or Structural Similarity more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: IQ motif and ubiquitin-like domain-containing protein; IQ and ubiquitin-like domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034130.1 → NP_001029302.1 IQ motif and ubiquitin-like domain-containing protein

See identical proteins and their annotated locations for NP_001029302.1

Status: PROVISIONAL

Source sequence(s)

BC099086

UniProtKB/Swiss-Prot

Q45GW3, Q4FZV4

Related

ENSRNOP00000063053.2, ENSRNOT00000064983.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

53897336..53962279 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107272.2 → XP_038963200.1 IQ and ubiquitin-like domain-containing protein isoform X1

Conserved Domains (1) summary

cl28922
Location:1 → 62

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_039107274.2 → XP_038963202.1 IQ and ubiquitin-like domain-containing protein isoform X2
XM_063285735.1 → XP_063141805.1 IQ and ubiquitin-like domain-containing protein isoform X3