Hils1 histone linker H1 domain, spermatid-specific 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hils1provided by RGD
Official Full Name: histone linker H1 domain, spermatid-specific 1provided by RGD
Primary source: RGD:1585185
See related: Ensembl:ENSRNOG00000024041 AllianceGenome:RGD:1585185
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: H1-9
Summary: Predicted to enable double-stranded DNA binding activity; histone binding activity; and nucleosomal DNA binding activity. Predicted to be involved in chromosome organization; gamete generation; and negative regulation of DNA recombination. Predicted to be located in male germ cell nucleus. Predicted to be part of nucleosome. Predicted to be active in nucleus. Orthologous to human H1-9P (H1.9 linker histone, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 10q26

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (80410361..80411157)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (79913525..79914321)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (82775691..82776487)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that HILS1 possesses significantly lower alpha-helicity compared to other linker histones but also show that HILS1 is a poor condenser of chromatin which demonstrate the idea that this particular linker histone variant may have distinct role in histone to protamine replacement.
Title: Spermatid-specific linker histone HILS1 is a poor condenser of DNA and chromatin and preferentially associates with LINE-1 elements.
Immunofluorescence studies demonstrate the presence of linker histone HILS1 and HILS1Y78p during different steps of spermiogenesis from early elongating to condensing spermatids.
Title: Mapping of post-translational modifications of spermatid-specific linker histone H1-like protein, HILS1.

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General gene information

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Markers

RH132356 (e-PCR)
- UniSTS:215639

BE106740 (e-PCR)
- UniSTS:246405

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	ISO Inferred from Sequence Orthology more info
enables nucleosomal DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromosome condensation	ISO Inferred from Sequence Orthology more info
involved_in germ cell development	ISO Inferred from Sequence Orthology more info
involved_in heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleosome assembly	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in male germ cell nucleus	ISO Inferred from Sequence Orthology more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: histone H1.9

Names: histone H1-like protein in spermatids 1; spermatid-specific linker histone H1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.