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    Zfp819 zinc finger protein 819 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308561, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Zfp819provided by RGD
    Official Full Name
    zinc finger protein 819provided by RGD
    Primary source
    RGD:1309564
    See related
    Ensembl:ENSRNOG00000030160 AllianceGenome:RGD:1309564
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309564
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription, DNA-templated and positive regulation of apoptotic process. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 89. Orthologous to human ZNF41 (zinc finger protein 41). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 40.5), Kidney (RPKM 21.6) and 9 other tissues See more
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    Genomic context

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    See Zfp819 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (103163570..103222203)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (94027347..94048767)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (99521177..99539232)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 658 Neighboring gene zinc finger protein 719 Neighboring gene uncharacterized LOC120099801 Neighboring gene CEA cell adhesion molecule 18 Neighboring gene sialic acid binding Ig-like lectin 8 Neighboring gene cytosolic thiouridylase subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of reproductive KRAB-ZF genes in mice. Jin S, et al. Gene, 2015 Jul 1. PMID 25827285
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 175

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014017.2 → NP_001014039.1  zinc finger protein 175

      See identical proteins and their annotated locations for NP_001014039.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087070
      UniProtKB/TrEMBL
      A0A9K3Y6N2, F7EPA9, Q5PQR1
      Related
      ENSRNOP00000024662.6, ENSRNOT00000024662.7
      Conserved Domains (5) summary
      smart00349
      Location:27 → 81
      KRAB; krueppel associated box
      COG5048
      Location:346 → 538
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:499 → 582
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:449 → 469
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:573 → 598
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      103163570..103222203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229046.5 → XP_006229108.1  zinc finger protein 175 isoform X1

      See identical proteins and their annotated locations for XP_006229108.1

      UniProtKB/TrEMBL
      A0A9K3Y6N2, F7EPA9, Q5PQR1
      Conserved Domains (5) summary
      smart00349
      Location:27 → 81
      KRAB; krueppel associated box
      COG5048
      Location:346 → 538
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:499 → 582
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:449 → 469
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:573 → 598
      zf-H2C2_2; Zinc-finger double domain

    2. XM_039111789.2 → XP_038967717.1  zinc finger protein 175 isoform X1

      UniProtKB/TrEMBL
      A0A9K3Y6N2, F7EPA9, Q5PQR1
      Conserved Domains (5) summary
      smart00349
      Location:27 → 81
      KRAB; krueppel associated box
      COG5048
      Location:346 → 538
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:499 → 582
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:449 → 469
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:573 → 598
      zf-H2C2_2; Zinc-finger double domain

    3. XM_063261749.1 → XP_063117819.1  zinc finger protein 175 isoform X2

    4. XM_017589129.3 → XP_017444618.1  zinc finger protein 175 isoform X1

      UniProtKB/TrEMBL
      A0A9K3Y6N2, F7EPA9, Q5PQR1
      Conserved Domains (5) summary
      smart00349
      Location:27 → 81
      KRAB; krueppel associated box
      COG5048
      Location:346 → 538
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:499 → 582
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:449 → 469
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:573 → 598
      zf-H2C2_2; Zinc-finger double domain

    5. XM_063261741.1 → XP_063117811.1  zinc finger protein 175 isoform X1

      UniProtKB/TrEMBL
      A0A9K3Y6N2, F7EPA9, Q5PQR1

    6. XM_063261747.1 → XP_063117817.1  zinc finger protein 175 isoform X1

      UniProtKB/TrEMBL
      A0A9K3Y6N2, F7EPA9, Q5PQR1

    7. XM_063261731.1 → XP_063117801.1  zinc finger protein 175 isoform X1

      UniProtKB/TrEMBL
      A0A9K3Y6N2, F7EPA9, Q5PQR1

    8. XM_006229047.5 → XP_006229109.1  zinc finger protein 175 isoform X1

      See identical proteins and their annotated locations for XP_006229109.1

      UniProtKB/TrEMBL
      A0A9K3Y6N2, F7EPA9, Q5PQR1
      Conserved Domains (5) summary
      smart00349
      Location:27 → 81
      KRAB; krueppel associated box
      COG5048
      Location:346 → 538
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:499 → 582
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:449 → 469
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:573 → 598
      zf-H2C2_2; Zinc-finger double domain

    9. XM_063261753.1 → XP_063117823.1  zinc finger protein 175 isoform X3

    RNA

    1. XR_010052073.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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