Foxa3 forkhead box A3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Foxa3provided by MGI
Official Full Name: forkhead box A3provided by MGI
Primary source: MGI:MGI:1347477
See related: Ensembl:ENSMUSG00000040891 AllianceGenome:MGI:1347477
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hnf3g; Tcf3g; Hnf-3g; Tcf-3g
Summary: Enables sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II and spermatogenesis. Acts upstream of or within several processes, including cellular glucose homeostasis; hematopoietic stem cell homeostasis; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; gut; and skeleton. Orthologous to human FOXA3 (forkhead box A3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in stomach adult (RPKM 32.1), colon adult (RPKM 31.9) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 9.46 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (18747208..18757464, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (19013283..19023539, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Dynamics of Transcriptional Activation by Hepatic Reprogramming Factors.
Title: The Dynamics of Transcriptional Activation by Hepatic Reprogramming Factors.
FOXA3 is a marker of the Sertoli cell lineage and of the adult Leydig cell population, and is a regulator of Pdgfra transcription in Leydig cells.
Title: FOXA3 Is Expressed in Multiple Cell Lineages in the Mouse Testis and Regulates Pdgfra Expression in Leydig Cells.
These findings reveal an obligatory coregulatory role of Foxa3 in the regulation of ER-alpha expression and of the Foxa3/ER-alpha cascade, at least in part, in the pathogenesis of androgen deficiency caused by type 2 diabetes mellitus.
Title: Regulation of testicular steroidogenesis by Foxa3 via transcriptional modulation of ERα signaling in type 2 diabetes mellitus (T2DM).
These results demonstrated the crucial role of Hnf1b and Foxa3 in hepatogenesis in vitro and provided a valuable tool for the efficient differentiation of HLCs from ES cells.
Title: Forced expression of Hnf1b/Foxa3 promotes hepatic fate of embryonic stem cells.
studies provide the first demonstration, to our knowledge, that Foxa3 is a direct target of GC action in adipose tissues and point to a role of Foxa3 as a mediator of the side effects induced in fat tissues by chronic treatment with synthetic steroids
Title: Forkhead box A3 mediates glucocorticoid receptor function in adipose tissue.
transcription factor Foxa3 was a strong promoter of liver regeneration.
Title: A genetic screen reveals Foxa3 and TNFR1 as key regulators of liver repopulation.
during aging, Foxa3 is up-regulated in brown and inguinal white fat depots, and midage Foxa3-null mice have increased white fat browning and thermogenic capacity, decreased adipose tissue expansion, improved insulin sensitivity, and increased longevity
Title: Role of forkhead box protein A3 in age-associated metabolic decline.
Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity in asthma and chronic obstructive pulmonary disease.
Title: Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity.
Foxa3 promotes adipocyte differentiation by cooperating with C/EBP beta and - delta to transcriptionally induce PPAR gamma expression.
Title: The winged helix transcription factor Foxa3 regulates adipocyte differentiation and depot-selective fat tissue expansion.
these results suggested that oxidative stress inhibited Akt signaling and facilitated the FOXO-3a/FBXO-dependent BK-beta(1) degradation in diabetic vessels.
Title: Reactive oxygen species signaling facilitates FOXO-3a/FBXO-dependent vascular BK channel β1 subunit degradation in diabetic mice.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Markers

Foxa3 (e-PCR), detects polymorphism
- UniSTS:532544

PMC316377P7 (e-PCR)
- UniSTS:272974

Foxa3 (e-PCR), detects polymorphism
- UniSTS:532314

UniSTS:235614 (e-PCR)
- UniSTS:235614

X74938 (e-PCR)
- UniSTS:159607

Foxa3 (e-PCR), detects polymorphism
- UniSTS:545936

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription factor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hematopoietic stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hepatocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: hepatocyte nuclear factor 3-gamma

Names: HNF-3-gamma; forkhead box protein A3; hepatocyte nuclear factor 3 gamma (winged helix transcription factor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.