TOPP4 type one serine/threonine protein phosphatase 4 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Gene symbol: TOPP4
Gene description: type one serine/threonine protein phosphatase 4
Primary source: Araport:AT2G39840
Locus tag: AT2G39840
See related: TAIR:AT2G39840
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: type one serine/threonine protein phosphatase 4
Summary: Encodes the catalytic subunit of a Type 1 phosphoprotein Ser/Thr phosphatase, expressed in roots, shoots and flowers.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See TOPP4 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 4

Sequence:: Chromosome: 2; NC_003071.7 (16627216..16629412)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

outline a novel phytochrome signaling mechanism by which TOPP4-mediated dephosphorylation of PIF5 attenuates phytochrome-dependent light responses
Title: TOPP4 Regulates the Stability of PHYTOCHROME INTERACTING FACTOR5 during Photomorphogenesis in Arabidopsis.
TOPP4-regulated PIN1 polar targeting through direct dephosphorylation is crucial for pavement cell morphogenesis in the Arabidopsis leaf.
Title: TYPE-ONE PROTEIN PHOSPHATASE4 regulates pavement cell interdigitation by modulating PIN-FORMED1 polarity and trafficking in Arabidopsis.
These studies provide direct evidence for a crucial role of protein dephosphorylation mediated by TOPP4 in the GA signaling pathway.
Title: Arabidopsis DELLA protein degradation is controlled by a type-one protein phosphatase, TOPP4.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

NM_129543.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within gibberellic acid mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein dephosphorylation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within red light signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within red light signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein phosphatase type 1 complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: type one serine/threonine protein phosphatase 4

NP_181514.1

type one serine/threonine protein phosphatase 4 (TOPP4); CONTAINS InterPro DOMAIN/s: Metallophosphoesterase (InterPro:IPR004843), Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (InterPro:IPR006186); BEST Arabidopsis thaliana protein match is: type one serine/threonine protein phosphatase 2 (TAIR:AT5G59160.3); Has 7176 Blast hits to 6978 proteins in 618 species: Archae - 78; Bacteria - 533; Metazoa - 2415; Fungi - 1410; Plants - 987; Viruses - 16; Other Eukaryotes - 1737 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

16627216..16629412

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_129543.3 → NP_181514.1 type one serine/threonine protein phosphatase 4 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_181514.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P48484, Q147H5

UniProtKB/TrEMBL

A0A178VUA1, A0A5S9X5I6

Conserved Domains (1) summary

cd07414
Location:18 → 308

MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain