Rbm45 RNA binding motif protein 45 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rbm45provided by RGD
Official Full Name: RNA binding motif protein 45provided by RGD
Primary source: RGD:628862
See related: Ensembl:ENSRNOG00000010595 AllianceGenome:RGD:628862
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Drb1
Summary: Predicted to enable RNA binding activity and identical protein binding activity. Involved in nervous system development. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of ribonucleoprotein complex. Orthologous to human RBM45 (RNA binding motif protein 45). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 155.8), Thymus (RPKM 140.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (81713214..81728190)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (61305973..61320950)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (63220660..63235638)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a new member of RRM-type neural RNA-binding protein
Title: cDNA cloning and characterization of Drb1, a new member of RRM-type neural RNA-binding protein.

Submit: New GeneRIF Correction

General gene information

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Markers

RH131062 (e-PCR)
- UniSTS:214345

RH136880 (e-PCR)
- UniSTS:218969

Drbp1 (e-PCR), detects polymorphism
- UniSTS:479100

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RNA-binding protein 45

Names: developmentally-regulated RNA-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153306.1 → NP_695218.1 RNA-binding protein 45

See identical proteins and their annotated locations for NP_695218.1

Status: PROVISIONAL

Source sequence(s)

AB036990

UniProtKB/Swiss-Prot

Q8CFD1

UniProtKB/TrEMBL

A6HMH3, G3V9K8

Related

ENSRNOP00000051270.1, ENSRNOT00000042968.3

Conserved Domains (4) summary

cd12366
Location:23 → 104

RRM1_RBM45; RNA recognition motif 1 in RNA-binding protein 45 (RBM45) and similar proteins

cd12367
Location:120 → 193

RRM2_RBM45; RNA recognition motif 2 in RNA-binding protein 45 (RBM45) and similar proteins

cd12368
Location:248 → 320

RRM3_RBM45; RNA recognition motif 3 in RNA-binding protein 45 (RBM45) and similar proteins

cd12369
Location:393 → 460

RRM4_RBM45; RNA recognition motif 4 in RNA-binding protein 45 (RBM45) and similar proteins