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    Arfrp1 ADP-ribosylation factor related protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117051, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Arfrp1provided by RGD
    Official Full Name
    ADP-ribosylation factor related protein 1provided by RGD
    Primary source
    RGD:621683
    See related
    Ensembl:ENSRNOG00000013992 AllianceGenome:RGD:621683
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in protein localization to Golgi apparatus; protein transport; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within gastrulation. Predicted to be located in membrane and trans-Golgi network. Predicted to be active in Golgi apparatus. Orthologous to human ARFRP1 (ADP ribosylation factor related protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 168.3), Lung (RPKM 146.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arfrp1 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (188844013..188851473, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168466351..168473960, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (176857667..176865105, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101833 Neighboring gene glucocorticoid modulatory element binding protein 2 Neighboring gene regulator of telomere elongation helicase 1 Neighboring gene stathmin 3 Neighboring gene zinc finger CCCH-type and G-patch domain containing Neighboring gene SLC2A4 regulator Neighboring gene Lck interacting transmembrane adaptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Roles of ARFRP1 (ADP-ribosylation factor-related protein 1) in post-Golgi membrane trafficking. Shin HW, et al. J Cell Sci, 2005 Sep 1. PMID 16129887
    2. Embryonic lethality caused by apoptosis during gastrulation in mice lacking the gene of the ADP-ribosylation factor-related protein 1. Mueller AG, et al. Mol Cell Biol, 2002 Mar. PMID 11839814, Free PMC Article
    3. ARP is a plasma membrane-associated Ras-related GTPase with remote similarity to the family of ADP-ribosylation factors. Schürmann A, et al. J Biol Chem, 1995 Dec 22. PMID 8530503
    4. Differential effects of depletion of ARL1 and ARFRP1 on membrane trafficking between the trans-Golgi network and endosomes. Nishimoto-Morita K, et al. J Biol Chem, 2009 Apr 17. PMID 19224922, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to plasma membrane protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Golgi to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gastrulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within gastrulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor-related protein 1
    Names
    ARF-related protein 1
    ARP
    NP_446432.1
    XP_006235780.1
    XP_038960051.2
    XP_038960052.1
    XP_063139078.1
    XP_063139079.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429718.1 → NP_001416647.1  ADP-ribosylation factor-related protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    2. NM_001429719.1 → NP_001416648.1  ADP-ribosylation factor-related protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8L2QAM9

    3. NM_001429721.1 → NP_001416650.1  ADP-ribosylation factor-related protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q63055
      UniProtKB/TrEMBL
      A0A8L2QAM9, A6KM17

    4. NM_053980.3 → NP_446432.1  ADP-ribosylation factor-related protein 1 isoform 1

      See identical proteins and their annotated locations for NP_446432.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q63055
      UniProtKB/TrEMBL
      A0A8L2QAM9, A6KM17
      Related
      ENSRNOP00000019038.3, ENSRNOT00000019038.6
      Conserved Domains (1) summary
      cd04160
      Location:19 → 186
      Arfrp1; Arf-related protein 1 (Arfrp1)

    RNA

    1. NR_190776.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      188844013..188851473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104123.2 → XP_038960051.2  ADP-ribosylation factor-related protein 1 isoform X1

    2. XM_006235718.4 → XP_006235780.1  ADP-ribosylation factor-related protein 1 isoform X4

      Conserved Domains (1) summary
      cd04160
      Location:19 → 186
      Arfrp1; Arf-related protein 1 (Arfrp1)

    3. XM_063283008.1 → XP_063139078.1  ADP-ribosylation factor-related protein 1 isoform X3

    4. XM_063283009.1 → XP_063139079.1  ADP-ribosylation factor-related protein 1 isoform X5

    5. XM_039104124.2 → XP_038960052.1  ADP-ribosylation factor-related protein 1 isoform X2

      Conserved Domains (1) summary
      cl38936
      Location:34 → 136
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. XR_591831.3 RNA Sequence

    2. XR_005501753.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63055.1 GenPept UniProtKB/Swiss-Prot:Q63055

    Gene LinkOut

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