Slc25a3 solute carrier family 25 member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc25a3provided by RGD
Official Full Name: solute carrier family 25 member 3provided by RGD
Primary source: RGD:70986
See related: Ensembl:ENSRNOG00000008797 AllianceGenome:RGD:70986
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Phc
Summary: Predicted to enable inorganic phosphate transmembrane transporter activity. Predicted to be involved in phosphate ion transmembrane transport. Located in mitochondrion. Orthologous to human SLC25A3 (solute carrier family 25 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 8555.8), Muscle (RPKM 4996.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q13

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (27499164..27506685, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (25611937..25619401, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (31816601..31824064, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Pi supply to mitochondria via PiC plays a critical role in ATP production and metabolism-secretion coupling in INS-1 cells.
Title: Role of mitochondrial phosphate carrier in metabolism-secretion coupling in rat insulinoma cell line INS-1.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables phosphate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables phosphate:proton symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphate:proton symporter activity	NAS Non-traceable Author Statement more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial phosphate ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in phosphate ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier family 25 member 3

Names: PTP; adenine nucleotide translocator), member 3; phosphate carrier protein, mitochondrial; phosphate transport protein; solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270788.1 → NP_001257717.1 solute carrier family 25 member 3 isoform 1

See identical proteins and their annotated locations for NP_001257717.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BC070918, CB577607

UniProtKB/TrEMBL

A0A0G2JYV5, A0A8I6GJ63, A6IFV2, Q6IRH6

Related

ENSRNOP00000070805.1, ENSRNOT00000080824.2

Conserved Domains (2) summary

PTZ00169
Location:65 → 332

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:59 → 147

Mito_carr; Mitochondrial carrier protein
NM_139100.2 → NP_620800.2 solute carrier family 25 member 3 isoform 2 precursor

See identical proteins and their annotated locations for NP_620800.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate in-frame exon in place of an internal exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is slightly shorter and has internal aa differences compared to isoform 1.

Source sequence(s)

BC070918, CB577607

UniProtKB/TrEMBL

A0A8I6GJ63, A6IFV1, G3V741

Related

ENSRNOP00000011494.1, ENSRNOT00000011494.5

Conserved Domains (2) summary

PTZ00169
Location:65 → 331

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:58 → 146

Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

27499164..27506685 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063262986.1 → XP_063119056.1 solute carrier family 25 member 3 isoform X2

UniProtKB/TrEMBL

A0A8I6GJ63
XM_063262985.1 → XP_063119055.1 solute carrier family 25 member 3 isoform X1

UniProtKB/TrEMBL

A0A8I6GJ63