Scn7a sodium voltage-gated channel alpha subunit 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Scn7aprovided by RGD
Official Full Name: sodium voltage-gated channel alpha subunit 7provided by RGD
Primary source: RGD:61922
See related: Ensembl:ENSRNOG00000029342 AllianceGenome:RGD:61922
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Na-G; Scn6a
Summary: Predicted to enable voltage-gated sodium channel activity. Predicted to be involved in membrane depolarization during action potential; neuronal action potential; and sodium ion transmembrane transport. Predicted to act upstream of or within response to bacterium and sodium ion homeostasis. Predicted to be located in glial cell projection and plasma membrane. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in axon. Orthologous to human SCN7A (sodium voltage-gated channel alpha subunit 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 437.9), Heart (RPKM 196.9) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q21

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (71743873..71846454, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (51335841..51438308, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (52775779..52877365, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NaX Channel Is a Physiological [Na[+]] Detector in Oxytocin- and Vasopressin-Releasing Magnocellular Neurosecretory Cells of the Rat Supraoptic Nucleus.
Title: Na(X) Channel Is a Physiological [Na(+)] Detector in Oxytocin- and Vasopressin-Releasing Magnocellular Neurosecretory Cells of the Rat Supraoptic Nucleus.
The sodium channel NaX : Possible player in excitation-contraction coupling.
Title: The sodium channel Na(X) : Possible player in excitation-contraction coupling.
The results of this study demonstrated that enhanced expression of SCN7A/Nax channel within distinct subpopulation of DRG neurons contributes to bone cancer pain by increasing the excitability of these neurons
Title: Enhanced SCN7A/Nax expression contributes to bone cancer pain by increasing excitability of neurons in dorsal root ganglion.
Data demonstrate predominant localisation of Na(V)1.6 and Na(V)1.7 on SGN cell bodies and Na(V)1.1 on axonal processes in rat brain.
Title: Voltage-gated sodium channel expression in rat spiral ganglion neurons.
This study shows that a neuronal population of the median preoptic nucleus acts as functional Na+ sensors and that the Na(X) channel might represent the molecular basis for the extracellular sodium level sensing in these neurons.
Title: Specific Na+ sensors are functionally expressed in a neuronal population of the median preoptic nucleus of the rat.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables osmolarity-sensing monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables osmolarity-sensing monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium channel activity	ISO Inferred from Sequence Orthology more info
enables sodium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables sodium channel activity	TAS Traceable Author Statement more info	PubMed
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
NOT enables voltage-gated channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated sodium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular homeostasis	ISO Inferred from Sequence Orthology more info
NOT involved_in membrane depolarization during action potential	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in neuronal action potential	IDA Inferred from Direct Assay more info	PubMed
involved_in osmosensory signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in osmosensory signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in sodium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in glial cell projection	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
NOT part_of voltage-gated sodium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated sodium channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sodium channel protein type 7 subunit alpha

Names: sodium channel voltage-gated type VI alpha polypeptide; sodium channel, voltage-gated, type 6, alpha polypeptide; sodium channel, voltage-gated, type VII, alpha subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001388508.1 → NP_001375437.1 sodium channel protein type 7 subunit alpha

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

F1LQQ7, P97706, Q01340, Q64074

UniProtKB/TrEMBL

A0A8I6GH51

Related

ENSRNOP00000044385.5, ENSRNOT00000041096.5

Conserved Domains (3) summary

cd13433
Location:1194 → 1245

Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits

pfam00520
Location:932 → 1203

Ion_trans; Ion transport protein

pfam06512
Location:742 → 926

Na_trans_assoc; Sodium ion transport-associated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

71743873..71846454 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105781.2 → XP_038961709.1 sodium channel protein type 7 subunit alpha isoform X3

UniProtKB/TrEMBL

A0A8I6GH51

Conserved Domains (3) summary

cd13433
Location:1158 → 1209

Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits

pfam00520
Location:504 → 738

Ion_trans; Ion transport protein

pfam06512
Location:742 → 926

Na_trans_assoc; Sodium ion transport-associated
XM_039105780.2 → XP_038961708.1 sodium channel protein type 7 subunit alpha isoform X2

UniProtKB/TrEMBL

A0A8I6GH51

Conserved Domains (3) summary

cd13433
Location:1194 → 1244

Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits

pfam00520
Location:932 → 1199

Ion_trans; Ion transport protein

pfam06512
Location:742 → 926

Na_trans_assoc; Sodium ion transport-associated
XM_039105778.2 → XP_038961706.1 sodium channel protein type 7 subunit alpha isoform X1

UniProtKB/Swiss-Prot

F1LQQ7, P97706, Q01340, Q64074

UniProtKB/TrEMBL

A0A8I6GH51

Conserved Domains (3) summary

cd13433
Location:1194 → 1245

Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits

pfam00520
Location:932 → 1203

Ion_trans; Ion transport protein

pfam06512
Location:742 → 926

Na_trans_assoc; Sodium ion transport-associated
XM_039105779.2 → XP_038961707.1 sodium channel protein type 7 subunit alpha isoform X1

UniProtKB/Swiss-Prot

F1LQQ7, P97706, Q01340, Q64074

UniProtKB/TrEMBL

A0A8I6GH51

Conserved Domains (3) summary

cd13433
Location:1194 → 1245

Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits

pfam00520
Location:932 → 1203

Ion_trans; Ion transport protein

pfam06512
Location:742 → 926

Na_trans_assoc; Sodium ion transport-associated
XM_063284500.1 → XP_063140570.1 sodium channel protein type 7 subunit alpha isoform X1

UniProtKB/Swiss-Prot

F1LQQ7, P97706, Q01340, Q64074
XM_063284501.1 → XP_063140571.1 sodium channel protein type 7 subunit alpha isoform X4
XM_063284502.1 → XP_063140572.1 sodium channel protein type 7 subunit alpha isoform X5