Nckap1 NCK-associated protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nckap1provided by RGD
Official Full Name: NCK-associated protein 1provided by RGD
Primary source: RGD:61939
See related: Ensembl:ENSRNOG00000007518 AllianceGenome:RGD:61939
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to contribute to small GTPase binding activity. Predicted to be involved in several processes, including Rac protein signal transduction; cortical actin cytoskeleton organization; and positive regulation of cellular component organization. Predicted to act upstream of or within several processes, including apical protein localization; embryonic morphogenesis; and segmentation. Predicted to be located in lamellipodium and ruffle. Predicted to be part of SCAR complex and filamentous actin. Predicted to be active in postsynapse. Orthologous to human NCKAP1 (NCK associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 858.2), Kidney (RPKM 696.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (85824333..85898748, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (65417450..65491769, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (67725180..67804680, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G67007 (e-PCR)
- UniSTS:178213

RH127961 (e-PCR)
- UniSTS:211271

BE105526 (e-PCR)
- UniSTS:261260

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
contributes_to small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Rac protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apical protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within basal protein localization	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration involved in gastrulation	ISO Inferred from Sequence Orthology more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell projection assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cortical actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic body morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic foregut morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic heart tube development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endoderm development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment or maintenance of actin cytoskeleton polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lamellipodium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesodermal cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within notochord development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within notochord morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within paraxial mesoderm development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within paraxial mesoderm morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lamellipodium assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein stabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somitogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within zygotic determination of anterior/posterior axis, embryo	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of SCAR complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCAR complex	IEA Inferred from Electronic Annotation more info
part_of SCAR complex	ISO Inferred from Sequence Orthology more info
part_of filamentous actin	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IMP Inferred from Mutant Phenotype more info	PubMed
located_in ruffle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nck-associated protein 1

Names: NAP 1; membrane-associated protein HEM-2; p125Nap1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031618.1 → NP_113806.1 nck-associated protein 1

See identical proteins and their annotated locations for NP_113806.1

Status: VALIDATED

Source sequence(s)

BC092610, BC107935, CB586461, D84346

UniProtKB/Swiss-Prot

P55161

UniProtKB/TrEMBL

A0A8I5ZLZ9, A6HMN0

Related

ENSRNOP00000079055.1, ENSRNOT00000114653.1

Conserved Domains (1) summary

pfam09735
Location:13 → 1122

Nckap1; Membrane-associated apoptosis protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

85824333..85898748 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105741.2 → XP_038961669.1 nck-associated protein 1 isoform X1

UniProtKB/Swiss-Prot

P55161

UniProtKB/TrEMBL

A0A8I5ZSX9, A6HMN1

Related

ENSRNOP00000081784.1

Conserved Domains (1) summary

pfam09735
Location:13 → 1128

Nckap1; Membrane-associated apoptosis protein
XM_039105743.2 → XP_038961671.1 nck-associated protein 1 isoform X3

UniProtKB/Swiss-Prot

P55161

Conserved Domains (1) summary

pfam09735
Location:13 → 1120

Nckap1; Membrane-associated apoptosis protein
XM_039105742.2 → XP_038961670.1 nck-associated protein 1 isoform X2

UniProtKB/Swiss-Prot

P55161

Conserved Domains (1) summary

pfam09735
Location:13 → 1126

Nckap1; Membrane-associated apoptosis protein
XM_063284423.1 → XP_063140493.1 nck-associated protein 1 isoform X4

UniProtKB/TrEMBL

A0A8I5ZXW3
XM_063284424.1 → XP_063140494.1 nck-associated protein 1 isoform X4

UniProtKB/TrEMBL

A0A8I5ZXW3