Sap30 Sin3A associated protein 30 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sap30provided by RGD
Official Full Name: Sin3A associated protein 30provided by RGD
Primary source: RGD:1595501
See related: Ensembl:ENSRNOG00000013218 AllianceGenome:RGD:1595501
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable transcription corepressor activity. Predicted to be involved in modulation by host of symbiont transcription. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II and skeletal muscle cell differentiation. Predicted to be located in nucleoplasm. Predicted to be part of histone deacetylase complex. Orthologous to human SAP30 (Sin3A associated protein 30). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 100.9), Thymus (RPKM 59.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (37758494..37763825)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (32747777..32753114)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (36115942..36121310)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in modulation by host of symbiont transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of histone deacetylase complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone deacetylase complex subunit SAP30

Names: Sin3A-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399275.1 → NP_001386204.1 histone deacetylase complex subunit SAP30

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A6KIV0, D3ZC08

Related

ENSRNOP00000017652.5, ENSRNOT00000017652.7

Conserved Domains (2) summary

pfam13866
Location:65 → 133

zf-SAP30; SAP30 zinc-finger

pfam13867
Location:153 → 205

SAP30_Sin3_bdg; Sin3 binding region of histone deacetylase complex subunit SAP30