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    Sertad2 SERTA domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498423, updated on 6-Jun-2024

    Summary

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    Symbol
    Sertad2provided by RGD
    Full Name
    SERTA domain containing 2provided by RGD
    Primary source
    RGD:1564049
    See related
    Ensembl:ENSRNOG00000005393 AllianceGenome:RGD:1564049
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transcription coactivator activity. Predicted to be involved in epigenetic maintenance of chromatin in transcription-competent conformation. Predicted to act upstream of or within negative regulation of cell growth and positive regulation of transcription, DNA-templated. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human SERTAD2 (SERTA domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 68.4), Lung (RPKM 62.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sertad2 in Genome Data Viewer
    Location:
    14q22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (98935428..99039536)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (94733637..94838200)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (104786649..104890022)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693208 Neighboring gene uncharacterized LOC134481873 Neighboring gene aftiphilin Neighboring gene ribosomal protein S28, pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SEI family of nuclear factors regulates p53-dependent transcriptional activation. Watanabe-Fukunaga R, et al. Genes Cells, 2005 Aug. PMID 16098148
    2. TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. Hsu SI, et al. EMBO J, 2001 May 1. PMID 11331592, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SERTA domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024903.1 → NP_001020074.2  SERTA domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      BC098047
      UniProtKB/TrEMBL
      A0A8I5ZWR0, F7F8X3
      Related
      ENSRNOP00000007162.4, ENSRNOT00000007162.5
      Conserved Domains (1) summary
      pfam06031
      Location:89 → 126
      SERTA; SERTA motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      98935428..99039536
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251526.5 → XP_006251588.1  SERTA domain-containing protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006251588.1

      UniProtKB/TrEMBL
      A6JQ25, Q4V7A7
      Related
      ENSRNOP00000087632.1
      Conserved Domains (2) summary
      PHA03381
      Location:83 → 172
      PHA03381; tegument protein VP22; Provisional
      pfam06031
      Location:40 → 75
      SERTA; SERTA motif

    2. XM_063273497.1 → XP_063129567.1  SERTA domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWR0, A0A8I6A0D3

    3. XM_039092326.1 → XP_038948254.1  SERTA domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A6JQ25, Q4V7A7
      Related
      ENSRNOP00000077181.1, ENSRNOT00000112480.1
      Conserved Domains (2) summary
      PHA03381
      Location:83 → 172
      PHA03381; tegument protein VP22; Provisional
      pfam06031
      Location:40 → 75
      SERTA; SERTA motif

    4. XM_039092325.2 → XP_038948253.1  SERTA domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A6JQ25, Q4V7A7
      Related
      ENSRNOP00000092548.1
      Conserved Domains (2) summary
      PHA03381
      Location:83 → 172
      PHA03381; tegument protein VP22; Provisional
      pfam06031
      Location:40 → 75
      SERTA; SERTA motif

    5. XM_063273498.1 → XP_063129568.1  SERTA domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A6JQ25, Q4V7A7
    Nucleotide Protein Strain
    Heading Accession and Version

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