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    Ascc1 activating signal cointegrator 1 complex subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294512, updated on 11-Apr-2024

    Summary

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    Symbol
    Ascc1provided by RGD
    Full Name
    activating signal cointegrator 1 complex subunit 1provided by RGD
    Primary source
    RGD:1359255
    See related
    Ensembl:ENSRNOG00000056647 AllianceGenome:RGD:1359255
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Asc-1; CGI-18
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in neuromuscular junction. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Barrett's esophagus. Orthologous to human ASCC1 (activating signal cointegrator 1 complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 92.9), Adrenal (RPKM 87.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ascc1 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (28484044..28574195)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (27941053..28031272)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (29558330..29648899)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483913 Neighboring gene DNA-damage-inducible transcript 4 Neighboring gene anaphase promoting complex subunit 16 Neighboring gene cytochrome c oxidase subunit 5B like 1 Neighboring gene uncharacterized LOC134483914 Neighboring gene SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2 Neighboring gene ribosomal protein S29, pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures. Knierim E, et al. Am J Hum Genet, 2016 Mar 3. PMID 26924529, Free PMC Article
    2. Novel transcription coactivator complex containing activating signal cointegrator 1. Jung DJ, et al. Mol Cell Biol, 2002 Jul. PMID 12077347, Free PMC Article
    3. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Hall JM, et al. Mol Interv, 2005 Dec. PMID 16394250
    4. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94577

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA alkylation repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA repair complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    activating signal cointegrator 1 complex subunit 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007632.2 → NP_001007633.1  activating signal cointegrator 1 complex subunit 1

      See identical proteins and their annotated locations for NP_001007633.1

      Status: VALIDATED

      Source sequence(s)
      BP504504, CB742862, CK357599
      UniProtKB/TrEMBL
      A0A8I5ZMZ0, A6K3W2, G3V619
      Related
      ENSRNOP00000075634.1, ENSRNOT00000085229.2
      Conserved Domains (3) summary
      PLN00108
      Location:128 → 355
      PLN00108; unknown protein; Provisional
      cd02394
      Location:61 → 119
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:132 → 355
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      28484044..28574195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098614.2 → XP_038954542.1  activating signal cointegrator 1 complex subunit 1 isoform X4

      Conserved Domains (2) summary
      pfam10469
      Location:165 → 281
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
      cd22419
      Location:91 → 156
      KH-I_ASCC1; type I K homology (KH) RNA-binding domain found in activating signal cointegrator 1 complex subunit 1 (ASCC1) and similar proteins

    2. XM_006256404.4 → XP_006256466.1  activating signal cointegrator 1 complex subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZMZ0
      Conserved Domains (3) summary
      PLN00108
      Location:161 → 388
      PLN00108; unknown protein; Provisional
      cd02394
      Location:94 → 152
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:165 → 388
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    3. XM_006256405.4 → XP_006256467.1  activating signal cointegrator 1 complex subunit 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZMZ0
      Conserved Domains (3) summary
      PLN00108
      Location:160 → 387
      PLN00108; unknown protein; Provisional
      cd02394
      Location:93 → 151
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:164 → 387
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    4. XM_063279072.1 → XP_063135142.1  activating signal cointegrator 1 complex subunit 1 isoform X5

    5. XM_006256407.5 → XP_006256469.2  activating signal cointegrator 1 complex subunit 1 isoform X3

      See identical proteins and their annotated locations for XP_006256469.2

      UniProtKB/TrEMBL
      A0A8I5ZMZ0, A6K3W2, G3V619
      Conserved Domains (3) summary
      PLN00108
      Location:128 → 355
      PLN00108; unknown protein; Provisional
      cd02394
      Location:61 → 119
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:132 → 355
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    6. XM_063279073.1 → XP_063135143.1  activating signal cointegrator 1 complex subunit 1 isoform X5

    7. XM_006256409.4 → XP_006256471.1  activating signal cointegrator 1 complex subunit 1 isoform X3

      See identical proteins and their annotated locations for XP_006256471.1

      UniProtKB/TrEMBL
      A0A8I5ZMZ0, A6K3W2, G3V619
      Conserved Domains (3) summary
      PLN00108
      Location:128 → 355
      PLN00108; unknown protein; Provisional
      cd02394
      Location:61 → 119
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:132 → 355
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    8. XM_008772881.4 → XP_008771103.1  activating signal cointegrator 1 complex subunit 1 isoform X3

      See identical proteins and their annotated locations for XP_008771103.1

      UniProtKB/TrEMBL
      A0A8I5ZMZ0, A6K3W2, G3V619
      Conserved Domains (3) summary
      PLN00108
      Location:128 → 355
      PLN00108; unknown protein; Provisional
      cd02394
      Location:61 → 119
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:132 → 355
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    9. XM_006256410.5 → XP_006256472.1  activating signal cointegrator 1 complex subunit 1 isoform X3

      See identical proteins and their annotated locations for XP_006256472.1

      UniProtKB/TrEMBL
      A0A8I5ZMZ0, A6K3W2, G3V619
      Conserved Domains (3) summary
      PLN00108
      Location:128 → 355
      PLN00108; unknown protein; Provisional
      cd02394
      Location:61 → 119
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:132 → 355
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    10. XM_006256408.5 → XP_006256470.1  activating signal cointegrator 1 complex subunit 1 isoform X3

      See identical proteins and their annotated locations for XP_006256470.1

      UniProtKB/TrEMBL
      A0A8I5ZMZ0, A6K3W2, G3V619
      Conserved Domains (3) summary
      PLN00108
      Location:128 → 355
      PLN00108; unknown protein; Provisional
      cd02394
      Location:61 → 119
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:132 → 355
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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