Drd3 dopamine receptor D3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Drd3provided by RGD
Official Full Name: dopamine receptor D3provided by RGD
Primary source: RGD:2521
See related: Ensembl:ENSRNOG00000060806 AllianceGenome:RGD:2521
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables D1 dopamine receptor binding activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; and protein domain specific binding activity. Involved in several processes, including adenylate cyclase-inhibiting dopamine receptor signaling pathway; regulation of secretion; and regulation of transcription by RNA polymerase II. Located in several cellular components, including apical part of cell; endocytic vesicle; and plasma membrane. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic density membrane. Used to study Parkinsonism; amnestic disorder; essential tremor; and hypertension. Biomarker of heroin dependence and visual epilepsy. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (dopamine receptor D3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 1.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 11q21

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (70385586..70437793, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (56879689..56931901, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (61819102..61883223, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dysregulation of striatal dopamine D2/D3 receptor-mediated by hypocretin induces depressive behaviors in rats.
Title: Dysregulation of striatal dopamine D2/D3 receptor-mediated by hypocretin induces depressive behaviors in rats.
Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer.
Title: Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer.
Genetic suppression of the dopamine D3 receptor in striatal D1 cells reduces the development of L-DOPA-induced dyskinesia.
Title: Genetic suppression of the dopamine D3 receptor in striatal D1 cells reduces the development of L-DOPA-induced dyskinesia.
Lentiviral-mediated up-regulation of let-7d microRNA decreases alcohol intake through down-regulating the dopamine D3 receptor.
Title: Lentiviral-mediated up-regulation of let-7d microRNA decreases alcohol intake through down-regulating the dopamine D3 receptor.
Differential effects of D-cycloserine and amantadine on motor behavior and D2/3 receptor binding in the nigrostriatal and mesolimbic system of the adult rat.
Title: Differential effects of D-cycloserine and amantadine on motor behavior and D(2/3) receptor binding in the nigrostriatal and mesolimbic system of the adult rat.
Autoradiography revealed an increased expression of D3R in 14-day-old Genetic Absence Epilepsy Rats From Strasbourg, before absence seizure onset, that persists in adulthood, as compared to age-matched non-epileptic controls.
Title: Early reduced dopaminergic tone mediated by D3 receptor and dopamine transporter in absence epileptogenesis.
Study confirms the 5alpha-reductase enzyme as a potential therapeutic target for treatment of dyskinesia in Parkinson's disease, suggesting the first ever evidence that neurosteroidogenesis may affect functional interaction between dopamine D1R and D3R.
Title: 5alpha-reductase inhibitors dampen L-DOPA-induced dyskinesia via normalization of dopamine D1-receptor signaling pathway and D1-D3 receptor interaction.
Study showed that while dopamine d2 receptor antagonism blocked, dopamine d3 receptor antagonism failed to impair cocaine-primed relapse.
Title: Differential involvement of D2 and D3 receptors during reinstatement of cocaine-seeking behavior in the Roman high- and low-avoidance rats.
D3R knockout (D3R(-/-)) mice displayed decreased freezing time of contextual fearing and anxiolytic effects following training sessions consisting of exposure to inescapable electric foot-shocks. Similarly, highly selective blockade of D3Rs by YQA14, a novel D3R antagonist, significantly ameliorated freezing and anxiogenic-like behaviours in the single-prolonged stress model of post-traumatic stress disorder in rats.
Title: Role of dopamine D3 receptor in alleviating behavioural deficits in animal models of post-traumatic stress disorder.
BDNF participates in the regulation of the dopamine system by acting on DRD3 and DAT.
Title: Changes in Expression of Dopamine, Its Receptor, and Transporter in Nucleus Accumbens of Heroin-Addicted Rats with Brain-Derived Neurotrophic Factor (BDNF) Overexpression.

Submit: New GeneRIF Correction See all GeneRIFs (60)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Drd3 (e-PCR), detects polymorphism
- UniSTS:142866

AU049053 (e-PCR)
- UniSTS:145501

RH71216 (e-PCR)
- UniSTS:53374

AU049859 (e-PCR)
- UniSTS:146305

DRD3-556F (e-PCR)
- UniSTS:34219

AU026331 (e-PCR)
- UniSTS:114385

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D1 dopamine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables dopamine neurotransmitter receptor activity	TAS Traceable Author Statement more info	PubMed
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go	IBA Inferred from Biological aspect of Ancestor more info
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go	IDA Inferred from Direct Assay more info	PubMed
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go	IEA Inferred from Electronic Annotation more info
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in acid secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating dopamine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenylate cyclase-activating dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in arachidonic acid secretion	IEA Inferred from Electronic Annotation more info
involved_in arachidonic acid secretion	ISO Inferred from Sequence Orthology more info
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to cocaine	IEA Inferred from Electronic Annotation more info
involved_in behavioral response to cocaine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to cocaine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within circadian regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in dopamine receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in intracellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within musculoskeletal movement, spinal reflex action	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating dopamine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytokinesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in prepulse inhibition	IEA Inferred from Electronic Annotation more info
involved_in prepulse inhibition	ISO Inferred from Sequence Orthology more info
involved_in regulation of biological quality	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of blood volume by renin-angiotensin	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dopamine secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of dopamine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of dopamine secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of locomotion	IEA Inferred from Electronic Annotation more info
involved_in regulation of locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter uptake	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	EXP Inferred from Experiment more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of potassium ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to amphetamine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to cocaine	ISO Inferred from Sequence Orthology more info
involved_in response to cocaine	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within response to ethanol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in response to histamine	IEA Inferred from Electronic Annotation more info
involved_in response to histamine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to morphine	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	TAS Traceable Author Statement more info	PubMed
involved_in synaptic transmission, dopaminergic	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in dopaminergic synapse	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: D(3) dopamine receptor

Names: dopaminergic receptor D3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017140.2 → NP_058836.1 D(3) dopamine receptor

See identical proteins and their annotated locations for NP_058836.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

P19020, P70647

UniProtKB/TrEMBL

A0A8L2R6V7, A6IR24

Related

ENSRNOP00000073117.2, ENSRNOT00000089057.2

Conserved Domains (1) summary

cd15310
Location:30 → 440

7tmA_D3_dopamine_R; D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors