Aspg asparaginase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aspgprovided by RGD
Official Full Name: asparaginaseprovided by RGD
Primary source: RGD:708388
See related: Ensembl:ENSRNOG00000012843 AllianceGenome:RGD:708388
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables acyltransferase activity, transferring groups other than amino-acyl groups; asparaginase activity; and carboxylic ester hydrolase activity. Involved in asparagine metabolic process and phospholipid metabolic process. Orthologous to human ASPG (asparaginase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 209.9), Kidney (RPKM 170.2) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (136997832..137017417)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (131176727..131196268)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (136682279..136701673)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

BG371487 (e-PCR)
- UniSTS:248731

AU049933 (e-PCR)
- UniSTS:146375

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables acyltransferase activity, transferring groups other than amino-acyl groups	IDA Inferred from Direct Assay more info	PubMed
enables asparaginase activity	IBA Inferred from Biological aspect of Ancestor more info
enables asparaginase activity	IDA Inferred from Direct Assay more info	PubMed
enables asparaginase activity	IEA Inferred from Electronic Annotation more info
enables asparaginase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lysophospholipase activity	IDA Inferred from Direct Assay more info	PubMed
enables lysophospholipase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidyl phospholipase B activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in asparagine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in aspartate family amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid metabolic process	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 60 kDa lysophospholipase

Names: asparaginase homolog; lysophospholipase; lysophospholipase-transacylase

NP_653351.1

EC 3.1.1.47

EC 3.1.1.5

EC 3.5.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144750.2 → NP_653351.1 60 kDa lysophospholipase

See identical proteins and their annotated locations for NP_653351.1

Status: PROVISIONAL

Source sequence(s)

AB009372

UniProtKB/Swiss-Prot

O88202, Q4G088

UniProtKB/TrEMBL

A0A0G2JSM2, A6KBU8

Related

ENSRNOP00000017454.2, ENSRNOT00000017454.5

Conserved Domains (3) summary

PLN03192
Location:381 → 550

PLN03192; Voltage-dependent potassium channel; Provisional

sd00045
Location:430 → 461

ANK; ANK repeat [structural motif]

cl00216
Location:15 → 361

L-asparaginase_like; Bacterial L-asparaginases and related enzymes