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    Wapl WAPL cohesin release factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290577, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Waplprovided by RGD
    Official Full Name
    WAPL cohesin release factorprovided by RGD
    Primary source
    RGD:1590924
    See related
    Ensembl:ENSRNOG00000052513 AllianceGenome:RGD:1590924
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wapal; RGD1308960
    Summary
    Predicted to be involved in several processes, including negative regulation of DNA replication; negative regulation of chromatin binding activity; and regulation of chromosome organization. Predicted to act upstream of or within several processes, including positive regulation of fibroblast proliferation; regulation of chromosome segregation; and response to toxic substance. Predicted to be located in several cellular components, including intercellular bridge; microtubule cytoskeleton; and nuclear lumen. Orthologous to human WAPL (WAPL cohesin release factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 407.2), Spleen (RPKM 367.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wapl in Genome Data Viewer
    Location:
    16p15
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (10011741..10081472)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (10005520..10075270)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (11029325..11108867)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 4, pseudogene 2 Neighboring gene opsin 4 Neighboring gene iron-sulfur cluster assembly 1, pseudogene 1 Neighboring gene cofilin 1, pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1. Shintomi K, et al. Genes Dev, 2009 Sep 15. PMID 19696148, Free PMC Article
    2. A dioxin sensitive gene, mammalian WAPL, is implicated in spermatogenesis. Kuroda M, et al. FEBS Lett, 2005 Jan 3. PMID 15620708
    3. Wapl is an essential regulator of chromatin structure and chromosome segregation. Tedeschi A, et al. Nature, 2013 Sep 26. PMID 23975099, Free PMC Article
    4. Cohesin acetylation speeds the replication fork. Terret ME, et al. Nature, 2009 Nov 12. PMID 19907496, Free PMC Article
    5. Wapl controls the dynamic association of cohesin with chromatin. Kueng S, et al. Cell, 2006 Dec 1. PMID 17113138

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP-dependent protein-DNA unloader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic sister chromatid segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    wings apart-like protein homolog
    Names
    wings apart-like homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427279.1 → NP_001414208.1  wings apart-like protein homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      D4ADT3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      10011741..10081472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006252726.5 → XP_006252788.2  wings apart-like protein homolog isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZZX5
      Related
      ENSRNOP00000083400.1
      Conserved Domains (1) summary
      pfam07814
      Location:595 → 955
      WAPL; Wings apart-like protein regulation of heterochromatin

    2. XM_006252725.5 → XP_006252787.2  wings apart-like protein homolog isoform X2

      Conserved Domains (1) summary
      pfam07814
      Location:640 → 1000
      WAPL; Wings apart-like protein regulation of heterochromatin

    3. XM_063275139.1 → XP_063131209.1  wings apart-like protein homolog isoform X4

    4. XM_006252724.5 → XP_006252786.2  wings apart-like protein homolog isoform X1

      UniProtKB/TrEMBL
      D4ADT3
      Related
      ENSRNOP00000070173.2
      Conserved Domains (1) summary
      pfam07814
      Location:646 → 1006
      WAPL; Wings apart-like protein regulation of heterochromatin
    Nucleotide Protein Strain
    Heading Accession and Version

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