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    Abhd6 abhydrolase domain containing 6, acylglycerol lipase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305795, updated on 2-May-2024

    Summary

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    Official Symbol
    Abhd6provided by RGD
    Official Full Name
    abhydrolase domain containing 6, acylglycerol lipaseprovided by RGD
    Primary source
    RGD:1359323
    See related
    Ensembl:ENSRNOG00000008167 AllianceGenome:RGD:1359323
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable acylglycerol lipase activity and phospholipase activity. Predicted to be involved in several processes, including monoacylglycerol catabolic process; negative regulation of cold-induced thermogenesis; and phospholipid metabolic process. Predicted to act upstream of or within long-term synaptic depression; negative regulation of cell migration; and regulation of endocannabinoid signaling pathway. Predicted to be located in late endosome membrane and lysosomal membrane. Predicted to be integral component of membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in GABA-ergic synapse; glutamatergic synapse; and mitochondrion. Predicted to be integral component of postsynaptic membrane. Orthologous to human ABHD6 (abhydrolase domain containing 6, acylglycerol lipase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 156.6), Kidney (RPKM 89.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Abhd6 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (19289967..19337500, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (16859740..16907094, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (18647903..18695133, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene PX domain containing serine/threonine kinase Neighboring gene ribonuclease P/MRP subunit p14 Neighboring gene deoxyribonuclease 1L3 Neighboring gene uncharacterized LOC103693818 Neighboring gene ATP6V1F neighbor like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phenotypic Characterization of the Endocannabinoid-Degrading Enzyme Alpha/Beta-Hydrolase Domain 6 Knockout Rat. Noguchi K, et al. Cannabis Cannabinoid Res, 2022 Apr. PMID 34468198, Free PMC Article
    2. α/β-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes. Zhao S, et al. Cell Rep, 2016 Mar 29. PMID 26997277
    3. α/β Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate. Pribasnig MA, et al. J Biol Chem, 2015 Dec 11. PMID 26491015, Free PMC Article
    4. The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome. Thomas G, et al. Cell Rep, 2013 Oct 31. PMID 24095738, Free PMC Article
    5. Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12). Navia-Paldanius D, et al. J Lipid Res, 2012 Nov. PMID 22969151, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phenotypic Characterization of the Endocannabinoid-Degrading Enzyme Alpha/Beta-Hydrolase Domain 6 Knockout Rat.
      Title: Phenotypic Characterization of the Endocannabinoid-Degrading Enzyme Alpha/Beta-Hydrolase Domain 6 Knockout Rat.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94917

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acylglycerol lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acylglycerol lipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acylglycerol catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acylglycerol catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in acylglycerol catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within long-term synaptic depression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lysobisphosphatidic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lysobisphosphatidic acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in monoacylglycerol catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoacylglycerol catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in phospholipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of endocannabinoid signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of retrograde trans-synaptic signaling by endocanabinoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of AMPA glutamate receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    monoacylglycerol lipase ABHD6
    Names
    2-arachidonoylglycerol hydrolase
    abhydrolase domain-containing protein 6
    NP_001007681.1
    XP_006251829.1
    XP_038949180.1
    XP_063130269.1
    XP_063130271.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007680.1 → NP_001007681.1  monoacylglycerol lipase ABHD6

      See identical proteins and their annotated locations for NP_001007681.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083826
      UniProtKB/Swiss-Prot
      Q5XI64
      UniProtKB/TrEMBL
      A0A8L2R9X1, A6K0C2
      Related
      ENSRNOP00000012271.3, ENSRNOT00000012271.5
      Conserved Domains (1) summary
      COG0596
      Location:51 → 327
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      19289967..19337500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251767.5 → XP_006251829.1  monoacylglycerol lipase ABHD6 isoform X1

      See identical proteins and their annotated locations for XP_006251829.1

      UniProtKB/Swiss-Prot
      Q5XI64
      UniProtKB/TrEMBL
      A0A8L2R9X1, A6K0C2
      Conserved Domains (1) summary
      COG0596
      Location:51 → 327
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

    2. XM_063274199.1 → XP_063130269.1  monoacylglycerol lipase ABHD6 isoform X2

    3. XM_039093252.2 → XP_038949180.1  monoacylglycerol lipase ABHD6 isoform X4

      Conserved Domains (1) summary
      PRK14875
      Location:1 → 179
      PRK14875; acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional

    4. XM_063274201.1 → XP_063130271.1  monoacylglycerol lipase ABHD6 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XI64.1 GenPept UniProtKB/Swiss-Prot:Q5XI64

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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