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    Aftph aftiphilin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305544, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Aftphprovided by RGD
    Official Full Name
    aftiphilinprovided by RGD
    Primary source
    RGD:1311920
    See related
    Ensembl:ENSRNOG00000005411 AllianceGenome:RGD:1311920
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311920
    Summary
    Predicted to enable clathrin binding activity. Predicted to be involved in intracellular transport. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be part of AP-1 adaptor complex. Predicted to be active in trans-Golgi network membrane. Orthologous to human AFTPH (aftiphilin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 370.1), Thymus (RPKM 259.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aftph in Genome Data Viewer
    Location:
    14q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (99072761..99127006, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (94871429..94925625, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (104921633..104975763, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481873 Neighboring gene SERTA domain containing 2 Neighboring gene ribosomal protein S28, pseudogene 5 Neighboring gene uncharacterized LOC102548772 Neighboring gene galectin-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The aftiphilin/p200/gamma-synergin complex. Hirst J, et al. Mol Biol Cell, 2005 May. PMID 15758025, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-1 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of AP-1 adaptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in trans-Golgi network membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    aftiphilin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305127.1 → NP_001292056.1  aftiphilin

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6JQ26
      Related
      ENSRNOP00000095783.1, ENSRNOT00000109170.1
      Conserved Domains (1) summary
      pfam15045
      Location:696 → 765
      Clathrin_bdg; Clathrin-binding box of Aftiphilin, vesicle trafficking

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      99072761..99127006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251532.5 → XP_006251594.1  aftiphilin isoform X1

      See identical proteins and their annotated locations for XP_006251594.1

      UniProtKB/TrEMBL
      A6JQ26, D3ZQQ1
      Related
      ENSRNOP00000053783.2
      Conserved Domains (2) summary
      pfam15045
      Location:696 → 765
      Clathrin_bdg; Clathrin-binding box of Aftiphilin, vesicle trafficking
      NF033845
      Location:366 → 611
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    2. XM_039092071.2 → XP_038947999.1  aftiphilin isoform X4

      UniProtKB/TrEMBL
      A0A8I6A421, A6JQ26
      Related
      ENSRNOP00000085437.1
      Conserved Domains (2) summary
      pfam15045
      Location:696 → 758
      Clathrin_bdg; Clathrin-binding box of Aftiphilin, vesicle trafficking
      NF033845
      Location:366 → 611
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    3. XM_039092070.2 → XP_038947998.1  aftiphilin isoform X3

      UniProtKB/TrEMBL
      A6JQ26
      Conserved Domains (2) summary
      pfam15045
      Location:696 → 758
      Clathrin_bdg; Clathrin-binding box of Aftiphilin, vesicle trafficking
      NF033845
      Location:366 → 611
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    4. XM_039092069.2 → XP_038947997.1  aftiphilin isoform X1

      UniProtKB/TrEMBL
      A6JQ26, D3ZQQ1
      Conserved Domains (2) summary
      pfam15045
      Location:696 → 765
      Clathrin_bdg; Clathrin-binding box of Aftiphilin, vesicle trafficking
      NF033845
      Location:366 → 611
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    5. XM_039092068.2 → XP_038947996.1  aftiphilin isoform X1

      UniProtKB/TrEMBL
      A6JQ26, D3ZQQ1
      Conserved Domains (2) summary
      pfam15045
      Location:696 → 765
      Clathrin_bdg; Clathrin-binding box of Aftiphilin, vesicle trafficking
      NF033845
      Location:366 → 611
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    6. XM_063273238.1 → XP_063129308.1  aftiphilin isoform X2

    7. XM_063273237.1 → XP_063129307.1  aftiphilin isoform X2

    RNA

    1. XR_005492976.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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