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    Tcf23 transcription factor 23 [ Mus musculus (house mouse) ]

    Gene ID: 69852, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Tcf23provided by MGI
    Official Full Name
    transcription factor 23provided by MGI
    Primary source
    MGI:MGI:1934960
    See related
    Ensembl:ENSMUSG00000006642 AllianceGenome:MGI:1934960
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Out; bHLHa24; 2010002O16Rik
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription regulator inhibitor activity. Involved in negative regulation of muscle cell differentiation and negative regulation of transcription by RNA polymerase II. Located in euchromatin. Is expressed in genitourinary system. Orthologous to human TCF23 (transcription factor 23). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in stomach adult (RPKM 8.3), ovary adult (RPKM 6.2) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tcf23 in Genome Data Viewer
    Location:
    5 B1; 5 16.9 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31125946..31145406)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30968602..30988062)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene cell growth regulator with EF hand domain 1 Neighboring gene STARR-positive B cell enhancer ABC_E1679 Neighboring gene abhydrolase domain containing 1 Neighboring gene prolactin regulatory element binding Neighboring gene STARR-seq mESC enhancer starr_12765 Neighboring gene solute carrier family 5 (sodium-dependent vitamin transporter), member 6 Neighboring gene STARR-positive B cell enhancer ABC_E2741 Neighboring gene all-trans retinoic acid induced differentiation factor Neighboring gene carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genomic organization and chromosomal mapping of the basic helix-loop-helix factor OUT (Tcf23/TCF23). Tachibana M, et al. Cytogenet Cell Genet, 2001. PMID 11701948
    2. OUT, a novel basic helix-loop-helix transcription factor with an Id-like inhibitory activity. Narumi O, et al. J Biol Chem, 2000 Feb 4. PMID 10652346
    3. A murine uterine transcriptome, responsive to steroid receptor coactivator-2, reveals transcription factor 23 as essential for decidualization of human endometrial stromal cells. Kommagani R, et al. Biol Reprod, 2014 Apr. PMID 24571987, Free PMC Article
    4. Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation. Stevens JD, et al. Differentiation, 2008 Nov. PMID 18557763, Free PMC Article
    5. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. transcription factor 23 (Tcf23), a basic-helix-loop-helix transcription factor, is a new progesterone-induced target gene that requires SRC-2 for full induction.
      Title: A murine uterine transcriptome, responsive to steroid receptor coactivator-2, reveals transcription factor 23 as essential for decidualization of human endometrial stromal cells.
    2. genomic organization and chromosome 2 mapping
      Title: Genomic organization and chromosomal mapping of the basic helix-loop-helix factor OUT (Tcf23/TCF23).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription regulator inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within decidualization ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in developmental process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within muscle organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor 23
    Names
    TCF-23
    basic helix-loop-helix transcription factor OUT
    ovary, uterus and testis protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053085.2 → NP_444315.1  transcription factor 23

      See identical proteins and their annotated locations for NP_444315.1

      Status: PROVISIONAL

      Source sequence(s)
      AC109606
      Consensus CDS
      CCDS19168.1
      UniProtKB/Swiss-Prot
      Q9JLR5
      Related
      ENSMUSP00000006818.3, ENSMUST00000006818.4
      Conserved Domains (1) summary
      smart00353
      Location:82 → 131
      HLH; helix loop helix domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      31125946..31145406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504095.4 → XP_006504158.1  transcription factor 23 isoform X1

      Conserved Domains (1) summary
      cd19709
      Location:77 → 132
      bHLH_TS_TCF23_OUT; basic helix-loop-helix (bHLH) domain found in transcription factor 23 (TCF-23) and similar proteins

    2. XM_006504096.4 → XP_006504159.1  transcription factor 23 isoform X2

      Conserved Domains (1) summary
      cd19709
      Location:33 → 88
      bHLH_TS_TCF23_OUT; basic helix-loop-helix (bHLH) domain found in transcription factor 23 (TCF-23) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JLR5.1 GenPept UniProtKB/Swiss-Prot:Q9JLR5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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